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Genetic lineage, bone mass, and physical activity in mice
Bone, 1995Five strains of inbred mice were found to have variations in bone mass although they were similar in body weight. Two of these strains, C57BL/6J and A/J, were studied in greater detail and the former had more bone in both femur and tibia. The increased bone mass was associated with larger quadriceps muscles in the C57BL/6J animals when measured at 18 ...
M, Kaye, R P, Kusy
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Genetic lineage tracing of resident stem cells by DeaLT
Nature Protocols, 2018Unraveling the fates of resident stem cells during tissue regeneration is an important objective in clinical and basic research. Genetic lineage tracing based on Cre-loxP recombination provides an effective strategy for inferring cell fate and cell conversion in vivo.
Lingjuan He +9 more
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Learning and Lineage Selection in Genetic Algorithms
Proceedings. IEEE SoutheastCon, 2005., 2005Lineage selection is a process by which traits that are not directly assessed by the fitness function can evolve. Reported here is an investigation of the effects of individual learning on the evolution of one such trait, self-adaptive mutation rates. It is found that the efficacy of the learning mechanism employed (its potential to increase individual
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Identification of genetically aberrant cell lineages in Wilms' tumors
Genes, Chromosomes and Cancer, 1994AbstractMost Wilms' tumors contain several predominant cell types, of which a primitive blastemal population is often the most prominent. Other typical components include undifferentiated mesenchymal and epithelial cells, but it has not been demonstrated that these components are neoplastic.
Weremowicz, S +5 more
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Genetic Lineage Tracing of Lymphatic Endothelial Cells in Mice
2018Lineage tracing allows for identification of all progeny produced by a single cell or groups of cells and can thus be used to assess developmental fate of cells. Here we focus on one of the most widely used lineage tracing approaches that utilize the Cre/loxP system for site-specific genetic recombination in studying the developmental origins of ...
Ines, Martinez-Corral, Taija, Makinen
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FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer
Cancer Cell, 2022Dong Gao
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Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states
Cancer Cell, 2021Kamen P Simeonov +2 more
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Lineage tracing meets single-cell omics: opportunities and challenges
Nature Reviews Genetics, 2020Daniel E Wagner, Allon M Klein
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Incomplete lineage sorting and phenotypic evolution in marsupials
Cell, 2022Shaohong Feng, Ming Bai, Shi-Ping Liu
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