Results 31 to 40 of about 314,656 (291)

Evolution of substrate specificity in a retained enzyme driven by gene loss. [PDF]

, 2017
The connection between gene loss and the functional adaptation of retained proteins is still poorly understood. We apply phylogenomics and metabolic modeling to detect bacterial species that are evolving by gene loss, with the finding that ...
Babnigg, Gyorgy, Barona-Gómez, Francisco, Carrillo-Tripp, Mauricio, Edirisinghe, Janaka N, Endres, Michael, Henry, Christopher S, Joachimiak, Andrzej, Juárez-Vázquez, Ana Lilia, Medina-Ruíz, Sofía, Michalska, Karolina, Noda-García, Lianet, Santoyo-Flores, Julián, Ton-That, Hung, Verduzco-Castro, Ernesto A, Wu, Chenggang   +14 more
core   +1 more source

High Expression of 92‐kDa Type IV Collagenase (Gelatinase) in the Osteoclast Lineage during Mouse Development [PDF]

Annals of the New York Academy of Sciences, 1994
cDNA clones for murine 92 kD type IV collagenase (gelatinase B) were generated for the determination of its primary structure and for analysis of temporal and spatial expression in vivo. The mouse enzyme has 72% sequence identity with the human counterpart, the major difference being the presence of a 16-residue segment absent from the human enzyme. In
P, Reponen, C, Sahlberg, C, Munaut, I, Thesleff, K, Tryggvason   +4 more
openaire   +3 more sources

Reassessment of the Columnea latent viroid (CLVd) Taxonomic Classification

Microorganisms, 2021
Columnea latent viroid (CLVd) is a member of the Pospiviroid family and its naked circular RNA genome typically forms native “rod-like” secondary structures.
Parichate Tangkanchanapas, Annelies Haegeman, Monica Höfte, Kris De Jonghe   +3 more
doaj   +1 more source

Phylogenetic analyses of typical bovine rotavirus genotypes G6, G10, P[5] and P[11] circulating in Argentinean beef and dairy herds [PDF]

, 2013
Group A rotavirus (RVA) is one of the main causes of neonatal calf diarrhea worldwide. RVA strains affecting Argentinean cattle mainly possess combinations of the G6, G10, P[5] and P[11] genotypes.
Badaracco, Alejandra, Bilbao, Gladys Noemí, Fernandez, Fernando, Garaicoechea, Lorena Laura, Louge Uriarte, Enrique Leopoldo, Matthijnssens, J., Odeón, Anselmo Carlos, Parra, G. I., Parreño, Gladys Viviana   +8 more
core   +1 more source

High crossreactivity of human T cell responses between Lassa virus lineages.

PLoS Pathogens, 2020
Lassa virus infects hundreds of thousands of people each year across rural West Africa, resulting in a high number of cases of Lassa fever (LF), a febrile disease associated with high morbidity and significant mortality.
Brian M Sullivan, Saori Sakabe, Jessica N Hartnett, Nhi Ngo, Augustine Goba, Mambu Momoh, John Demby Sandi, Lansana Kanneh, Beatrice Cubitt, Selma D Garcia, Brian C Ware, Dylan Kotliar, Refugio Robles-Sikisaka, Karthik Gangavarapu, Luis Branco, Philomena Eromon, Ikponmwosa Odia, Ephraim Ogbaini-Emovon, Onikepe Folarin, Sylvanus Okogbenin, Peter O Okokhere, Christian Happi, Juan Carlos de la Torre, Pardis C Sabeti, Kristian G Andersen, Robert F Garry, Donald S Grant, John S Schieffelin, Michael B A Oldstone   +28 more
doaj   +1 more source

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. [PDF]

, 2017
After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II
Brumwell, Alexis N, Chapman, Harold A, Driver, Ian H, Gotts, Jeffrey E, Jackson, Julia R, Kim, Thomas, Lee, Dong-Kee, Matthay, Michael A, Shannon, John M, Tan, Victor, Vaughan, Andrew E, Wei, Ying, Xi, Ying, Xu, Jianming   +13 more
core   +1 more source

Emergence of peste des petits ruminants virus lineage IV in Ismailia Province, Egypt

Infection, Genetics and Evolution, 2014
Peste des petits ruminants (PPR) is an acute, highly contagious fatal disease of small ruminants characterized by high fever, ocular and nasal discharge, pneumonia, erosive stomatitis and severe enteritis that ultimately results in high mortalities. Peste des petits ruminants virus (PPRV) is widely distributed and endemic in several African, middle ...
Mohamed A, Soltan, Mohamed M, Abd-Eldaim
openaire   +2 more sources

Recombination and positive selection contributed to the evolution of Listeria monocytogenes lineages III and IV, two distinct and well supported uncommon L. monocytogenes lineages [PDF]

Infection, Genetics and Evolution, 2011
Listeriamonocytogenes lineages III and IV represent two uncommon lineages of the human and animal pathogen L. monocytogenes, characterized by occurrence of unusual phenotypic and genetic characteristics that differentiate them from the common lineages I and II.
Yeu-Harn Lucy, Tsai, Steve B, Maron, Patrick, McGann, Kendra K, Nightingale, Martin, Wiedmann, Renato H, Orsi   +5 more
openaire   +2 more sources

Comparative Analysis of G1P[8] Rotaviruses Identified Prior to Vaccine Implementation in Pakistan With Rotarix™ and RotaTeq™ Vaccine Strains

Frontiers in Immunology, 2020
Group A rotavirus (RVA) is the leading cause of severe childhood diarrhea globally, even with all effective interventions, particularly in developing countries. Among the diverse genotypes of RVA, G1P[8] is a common genotype that has continued to pervade
Asma Sadiq, Nazish Bostan
doaj   +1 more source

The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration. [PDF]

, 2019
Metabolic reprogramming is an active regulator of stem cell fate choices, and successful stem cell differentiation in different compartments requires the induction of oxidative phosphorylation.
Cunningham, Thomas J, Dall'Agnese, Alessandra, Duester, Gregg, Etxaniz, Usue, Latella, Lucia, Nicoletti, Chiara, Puri, Pier Lorenzo, Sacco, Alessandra, Sala, David, Stec, Michael J   +9 more
core   +3 more sources