Results 61 to 70 of about 314,656 (291)

Differential adhesion during development establishes individual neural stem cell niches and shapes adult behaviour in Drosophila.

open access: yesPLoS Biology, 2023
Neural stem cells (NSCs) reside in a defined cellular microenvironment, the niche, which supports the generation and integration of newborn neurons. The mechanisms building a sophisticated niche structure around NSCs and their functional relevance for ...
Agata Banach-Latapy   +4 more
doaj   +1 more source

Distribution and genetic diversity of Peste des Petits Ruminants virus in Mali [PDF]

open access: yes, 2017
Peste de Petits Ruminants (PPR) is a highly contagious infectious disease of sheep and goats. The disease is endemic in Africa, Middle East and Asia (Libeau, Diallo et al. 2014).
Bataille, Arnaud   +3 more
core  

Parallel Evolution of a Type IV Secretion System in Radiating Lineages of the Host-Restricted Bacterial Pathogen Bartonella [PDF]

open access: yesPLoS Genetics, 2011
Adaptive radiation is the rapid origination of multiple species from a single ancestor as the result of concurrent adaptation to disparate environments. This fundamental evolutionary process is considered to be responsible for the genesis of a great portion of the diversity of life.
Engel, Philipp   +10 more
openaire   +8 more sources

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack   +39 more
wiley   +1 more source

Rate variation during molecular evolution: creationism and the cytochrome c molecular clock [PDF]

open access: yes, 2017
Molecular clocks based upon amino acid sequences in proteins have played a major role in the clarification of evolutionary phylogenies. Creationist criticisms of these methods sometimes rely upon data that might initially seem to be paradoxical.
Hofmann James, R.
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Monoclonal antibody therapy demonstrates increased virulence of a lineage VII strain of Lassa virus in nonhuman primates

open access: yesEmerging Microbes and Infections
Lassa virus (LASV) is a World Health Organization (WHO) priority pathogen that causes high morbidity and mortality. Recently, we showed that a combination of three broadly neutralizing human monoclonal antibodies known as Arevirumab-3 (8.9F, 12.1F, 37.2D)
Courtney Woolsey   +13 more
doaj   +1 more source

Molecular Evolution of Peste des Petits Ruminants Virus

open access: yesEmerging Infectious Diseases, 2014
Despite safe and efficacious vaccines against peste des petits ruminants virus (PPRV), this virus has emerged as the cause of a highly contagious disease with serious economic consequences for small ruminant agriculture across Asia, the Middle East, and ...
Murali Muniraju   +12 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Emergence and diversification of dengue 2 cosmopolitan genotype in Pakistan, 2011. [PDF]

open access: yesPLoS ONE, 2013
Major dengue epidemics have been observed in the Indian subcontinent since the 1980s and have occurred with increased hospitalizations and mortality. In 2011, the first major epidemic of dengue occurred in Lahore, the second largest city in Pakistan, and
Mohammad A Khan   +10 more
doaj   +1 more source

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