Results 121 to 130 of about 5,206,546 (317)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Landau-Pomeranchuk-Migdal effect and suppression of beamstrahlung and bremsstrahlung in linear colliders

open access: yes, 1992
It is well known that beamstrahlung and bremsstrahlung take place over a finite formation zone distance. If something disturbs the electron during this time, the emission can be suppressed.
Chen, Pisin (Stanford Linear Accelerator Center, Menlo Park, CA (United States))   +1 more
core  

GM1 and GM2 gangliosides: recent developments

open access: yesBiomolecular Concepts, 2014
GM1 and GM2 gangliosides are important components of the cell membrane and play an integral role in cell signaling and metabolism. In this conceptual overview, we discuss recent developments in our understanding of the basic biological functions of GM1 ...
Bisel Blaine   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Linear Transformations

open access: yes, 2001
Using Maple or Mathmatica, learner should be able to examine linear transformations, particularly those from R2 to ...
Smith, David
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Multivariate Linear Hypothesis with Linear Restrictions

open access: yesJournal of the Royal Statistical Society Series B: Statistical Methodology, 1963
SUMMARY In this paper we consider a normal multivariate linear regression model and give a criterion for the simultaneous testing of a set of linear estimable parametric functions. We also derive the distribution of the criterion and obtain some allied results.
openaire   +2 more sources

Numer. Linear Algebra w/Appl.

open access: yes, 2013
Aims and Scope Manuscripts submitted to Numerical Linear Algebra with Applications should include large-scale broad-interest applications in which challenging computational results are integral to the approach investigated and analysed.
SIMONCINI, VALERIA
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Linear Algebra

open access: yes, 2012
This course introduces the student to the study of linear algebra. Practically every modern technology relies on linear algebra to simplify the computations required for internet searches, 3-D animation, coordination of safety systems, financial trading,
The Saylor Foundation
core  

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