Results 161 to 170 of about 2,113,636 (278)

AI for NONMEM Coding in Pharmacometrics Research and Education: Shortcut or Pitfall? [PDF]

CPT Pharmacometrics Syst Pharmacol
Zheng W, Wang W, Kirkpatrick CMJ, Landersdorfer CB, Yao H, Zhou J.   +5 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The cost of explainability in artificial intelligence-enhanced electrocardiogram models. [PDF]

NPJ Digit Med
Patlatzoglou K, Pastika L, Barker J, Sieliwonczyk E, Khattak GR, Zeidaabadi B, Ribeiro AH, Ware JS, Peters NS, Ribeiro ALP, Kramer DB, Waks JW, Sau A, Ng FS.   +13 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Software for dataset-wide XAI: From local explanations to global insights with Zennit, CoRelAy, and ViRelAy. [PDF]

PLoS One
Anders CJ, Neumann D, Samek W, Müller KR, Lapuschkin S.   +4 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

A Turing Test for artificial nets devoted to vision. [PDF]

Front Artif Intell
Vila-Tomás J, Hernández-Cámara P, Li Q, Laparra V, Malo J.   +4 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Room-temperature polariton condensate in a quasi-2D hybrid perovskite. [PDF]

Nat Commun
Struve M, Bennenhei C, Pashaei Adl H, Song KW, Shan H, Matukhno N, Drawer JC, Stephan S, Eilenberger F, Jasti NP, Cahen D, Kyriienko O, Schneider C, Esmann M.   +13 more
europepmc   +1 more source