Results 81 to 90 of about 3,215,324 (277)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

A novel approach to establishing uniqueness of solutions in linear complementarity problems

Mathematics Open
Linear complementarity problems are fundamental in various mathematical fields, and it is widely recognized that these problems have a unique solution if and only if the matrix related to them is a P-matrix.
Yamna Achik, Imane Agmour, Youssef El Foutayeni   +2 more
doaj   +1 more source

A dual-algorithmic neutrosophic structured element framework for solving linear complementarity problems [PDF]

Journal of Fuzzy Extension and Applications
The Linear Complementarity Problem (LCP) is a cornerstone in optimization, game theory, and variational inequalities. Existing fuzzy and neutrosophic extensions improve uncertainty handling, but they often lack a structured formulation that ensures ...
Areen Al-khateeb
doaj   +1 more source

A Fast Algorithm for Solving a Class of the Linear Complementarity Problem in a Finite Number of Steps

Abstract and Applied Analysis, 2020
The linear complementarity problem is receiving a lot of attention and has been studied extensively. Recently, El foutayeni et al. have contributed many works that aim to solve this mysterious problem.
Yamna Achik, Asmaa Idmbarek, Hajar Nafia, Imane Agmour, Youssef El foutayeni   +4 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Linear complementarity problems and bi-linear games [PDF]

, 1994
summary:In this paper, we define bi-linear games as a generalization of the bimatrix games. In particular, we generalize concepts like the value and equilibrium of a bimatrix game to the general linear transformations defined on a finite dimensional ...
Sengodan, Gokulraj, Arumugasamy, Chandrashekaran, Robert J. Plemmons, Shekhar, Vaibhav, Liu, Jianzhou, Mishra, Nachiketa, Abraham Berman, Mishra, Debasisha, Zeng, Wenlong   +8 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Flexure and shear response of an impulsively loaded rigid-plastic beam by enhanced linear complementarity approach. [PDF]

Sci Rep, 2022
Khan A, Tariq M, Ullah A, Khan NB, Jameel M.   +4 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source