Results 61 to 70 of about 3,215,324 (277)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Absolute Value Equations [PDF]
, 2005 We investigate existence and nonexistence of solutions for NP-hard equations in- volving absolute values of variables: Ax ? |x| = b, where A is an arbitrary n n real matrix.
Mangasarian, Olvi +3 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Algorithms and Environments for Complementarity [PDF]
, 2000 Complementarity problems arise in a wide variety of disciplines. Prototypical examples include theWardropian andWalrasian equilibrium models encountered in the engineering and economic disciplines and the first order optimality conditions for nonlinear
Munson, Todd
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Projective algorithms for solving complementarity problems
International Journal of Mathematics and Mathematical Sciences, 2002 We present robust projective algorithms of the von Neumann type for the linear complementarity problem and for the generalized linear complementarity problem.
Caroline N. Haddad, George J. Habetler
doaj +1 more source
The Ill-Posed Linear Complementarity Problem [PDF]
, 1995 A regularization of the linear complementarity problem (LCP) is proposed that leads to an exact solution, if one exists, otherwise a minimizer of a natural residual of the problem is obtained.
Mangasarian, Olvi L.
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
SAGE Open, 2016 When could it be safe to report ordinal scores instead of linear measures? In this study, preschool gains measured with ordinal scores were compared with residualized gain scores, as well as Rasch model measures of linear change (logits) to clarify ...
Nikolaus Bezruczko +2 more
doaj +1 more source