Results 101 to 110 of about 5,890,937 (282)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Linear combination of composition operators on $H^\infty$ and the Bloch space
, 2018 Let $λ_i (i=1,...,k)$ be any nonzero complex scalars and $φ_i (i=1,..,k)$ be any analytic self-maps of the unit disk $\mathbb{D}$. We show that the operator $\sum_{i=1}^kλ_iC_{φ_i}$ is compact on the Bloch space $\mathcal{B}$ if and only if $$\lim_{n\to\infty}\|λ_1φ_1^n+λ_2φ_2^n+...+λ_kφ_k^n\|_{\mathcal{B}}=0.$$ We also study the linear combination of ...
Shi, Yecheng, Li, Songxiao
openaire +3 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Essential spectra of quasi-parabolic composition operators on Hardy spaces of the Poly-disc
, 2013 In this paper we study the essential spectra of a class of composition operators on the Hilbert-Hardy space of the hi-disc which is called "quasi-parabolic" and whose one variable analogue was studied in [2].
Uğur Gül, Gul, Ugur
core +1 more source
Differential Operators and Differential Calculus on $delta-$Hom-Jordan-Lie Superalgebras
پژوهشهای ریاضی, 2020 Introduction Hom-algebraic structures appeared first as a generalization of Lie algebras in [1,3], where the authors studied q-deformations of Witt and Virasoro algebras. A general study and construction of Hom-Lie algebras
Valiollah Khalili
doaj
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Norms of composition operators with rational symbol
, 2006 We compute the norms of composition operators with rational symbols that satisfy certain properties, extending Christopher Hammond's methods on operators with linear fractional symbols.
Effinger-Dean, Sean +3 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source