Results 101 to 110 of about 13,906 (254)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Cyclic behavior of linear fractional composition operators

, 2001
Let \(\mathbb{C}\) denote the plane of complex numbers, and for real number \(v\), and analytic functions \(f\), \(g\) representable as \[ f(z)= \sum\{a_nz^n, n= 0,1,2,\dots\},\quad g(z)= \sum\{b_n z^n, n= 0,1,\dots,\}, \] let \((f|g)_v= \sum\{(a_n b_n(n+ 1)^{2v}, n= 0,1,\dots\}\), \(\|f\|^2_v= \sum\{|a_n|^2(n+ 1)^{2v}, n= 0,1,2,\dots\}\).
Gallardo Gutiérrez, Eva Antonia, Montes Rodríguez, Alfonso   +1 more
openaire   +4 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The first-order differential isomorphisms of canonical hyperbolic equations

Известия высших учебных заведений. Поволжский регион: Физико-математические науки
Background. To determine unknown solutions of canonical hyperbolic differential equations for functions of two variables, it seemed relevant to establish the connection of the first-order differential isomorphisms of these equations with Laplace ...
Aleksandr I. Fomin, Vera I. Titarenko
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Comprehensive Analysis of Potential Revenue and Breakeven Viability of Energy Storage in the Day‐Ahead Market of MISO

IET Renewable Power Generation
This study investigates the economic feasibility of Energy Storage Systems (ESS) in volatile market nodes within the Midcontinent Independent System Operator (MISO).
Muhammad Zubair, Mateus L. de Sousa, Maurício B. C. Salles   +2 more
doaj   +1 more source

A class of linear fractional maps of the ball and their composition operators

Advances in Mathematics, 2007
Let \(A = (a_{i,j})\) be an \(N \times N\)-matrix, \(B + (b_j), \mathbb C = (c_j)\) be \(N\)-column vectors, and \(d\) be a complex number. A linear fractional map of \(\mathbb C^n\) is a map of the form \[ u(z) = \frac{Az + B}{\langle z,\overline{\mathbb C}\rangle + d}, \] where \(\langle.,.\rangle\) is the Hermitian product in \(\mathbb C^n.\) The ...
openaire   +3 more sources