Results 81 to 90 of about 13,725 (250)

Resolvent Compositions for Positive Linear Operators

Resolvent compositions were recently introduced as monotonicity-preserving operations that combine a set-valued monotone operator and a bounded linear operator. They generalize in particular the notion of a resolvent average. We analyze the resolvent compositions when the monotone operator is a positive linear operator.
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Differential Operators and Differential Calculus on $delta-$Hom-Jordan-Lie Superalgebras

پژوهش‌های ریاضی, 2020
Introduction Hom-algebraic ‎structures ‎appeared ‎first ‎as a‎ ‎generalization ‎of ‎Lie ‎algebras ‎in [1,3],  ‎where ‎the ‎authors ‎studied ‎‎q-deformations ‎of ‎Witt ‎and ‎Virasoro ‎algebras. A‎ ‎general ‎study ‎and ‎construction ‎of ‎Hom-Lie ‎algebras ‎
Valiollah Khalili
doaj  

Linear combination of composition operators on $H^\infty$ and the Bloch space

, 2018
Let $λ_i (i=1,...,k)$ be any nonzero complex scalars and $φ_i (i=1,..,k)$ be any analytic self-maps of the unit disk $\mathbb{D}$. We show that the operator $\sum_{i=1}^kλ_iC_{φ_i}$ is compact on the Bloch space $\mathcal{B}$ if and only if $$\lim_{n\to\infty}\|λ_1φ_1^n+λ_2φ_2^n+...+λ_kφ_k^n\|_{\mathcal{B}}=0.$$ We also study the linear combination of ...
Shi, Yecheng, Li, Songxiao
openaire   +3 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A bilinear Bogolyubov-Ruzsa lemma with polylogarithmic bounds

Discrete Analysis, 2019
A bilinear Bogolyubov-Ruzsa lemma with polylogarithmic bounds, Discrete Analysis 2019:10, 14 pp. The Bogolyubov-Ruzsa lemma in additive combinatorics states that if $A$ is a subset of density $\alpha$ of $\mathbb{F}^n$, where $\mathbb{F}$ is a finite ...
Kaave Hosseini, Shachar Lovett
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source