Results 81 to 90 of about 237,939 (264)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
A Berezin-type map and a class of weighted composition operators
Concrete Operators, 2017 In this paper we consider the map L defined on the Bergman space La2(+)$L_a^2({{\rm\mathbb{C}}_{\rm{ + }}})$ of the right half plane ℂ+ by (Lf)(w)=πM′(w)∫+(fM′)(s)|bw(s)|2dA˜(s)$(Lf)(w) = \pi M'(w)\int\limits_{{{\rm\mathbb{C}}_{\rm{ + }}}} {\left( {{f \
Das Namita
doaj +1 more source
Smoothing technique for nonsmooth composite minimization with linear operator
, 2017 26 pages, 5 ...
Van Nguyen, Quang +2 more
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Electronic Journal of Differential Equations, 2018 In this article we study applications of integral transforms composition method (ITCM) for obtaining transmutations via integral transforms. It is possible to derive wide range of transmutation operators by this method.
Ahmed Fitouhi +3 more
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
On a Schrödinger Equation in the Complex Space Variable
AppliedMathWe study a separable Hilbert space of smooth curves taking values in the Segal–Bergmann space of analytic functions in the complex plane, and two of its subspaces that are the domains of unbounded non self-adjoint linear partial differential operators of
Manuel L. Esquível +2 more
doaj +1 more source
Complex symmetric composition operators induced by linear fractional transformations
, 2016 16 pages.
Gao, Yong-Xin, Zhou, Ze-Hua
openaire +2 more sources