Results 71 to 80 of about 13,906 (254)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The Goursat problem for hyperbolic linear third order equations

Mathematical Modelling and Analysis, 2001
The third order hyperbolic linear differential equation is considered in the non‐cylindrical domain of multidimensional Euclidean space. The equation operator is a composition of a differentiation operator of the first order and second order operator ...
V. I. Korzyuk
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Applications of the integral transforms composition method to wave-type singular differential equations and index shift transmutations

Electronic Journal of Differential Equations, 2018
In this article we study applications of integral transforms composition method (ITCM) for obtaining transmutations via integral transforms. It is possible to derive wide range of transmutation operators by this method.
Ahmed Fitouhi, Iness Jebabli, Elina L. Shishkina, Sergei M. Sitnik   +3 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

On a Schrödinger Equation in the Complex Space Variable

AppliedMath
We study a separable Hilbert space of smooth curves taking values in the Segal–Bergmann space of analytic functions in the complex plane, and two of its subspaces that are the domains of unbounded non self-adjoint linear partial differential operators of
Manuel L. Esquível, Nadezhda P. Krasii, Philippe L. Didier   +2 more
doaj   +1 more source

A Berezin-type map and a class of weighted composition operators

Concrete Operators, 2017
In this paper we consider the map L defined on the Bergman space La2(𝔺+)$L_a^2({{\rm\mathbb{C}}_{\rm{ + }}})$ of the right half plane ℂ+ by (Lf)(w)=πM′(w)∫𝔺+(fM′)(s)|bw(s)|2dA˜(s)$(Lf)(w) = \pi M'(w)\int\limits_{{{\rm\mathbb{C}}_{\rm{ + }}}} {\left( {{f \
Das Namita
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The Interpolative Ideal of Bloch Mappings

Journal of Function Spaces
Inspired by the interpolative ideal procedure for linear operators due to Matter, the concept of interpolative ideals of a Banach normalized Bloch ideal IB∧ is introduced.
D. Achour, M. G. Cabrera-Padilla, A. Jiménez-Vargas   +2 more
doaj   +1 more source