Results 51 to 60 of about 77,454 (294)
Molecular Therapy: Methods & Clinical Development, 2020 Potency assessment of clinical-grade vector lots is crucial to support adeno-associated virus (AAV) vector release and is required for future marketing authorization.
Sem J. Aronson +13 more
doaj +1 more source
Polymers for Protein Conjugation [PDF]
, 2014 Polyethylene glycol (PEG) at the moment is considered the leading polymer for protein conjugation in view of its unique properties, as well as to its low toxicity in humans, qualities which have been confirmed by its extensive use in clinical practice ...
PASUT, GIANFRANCO, Gianfranco Pasut
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Idempotents in a space with conjugation [PDF]
, 2013 Let H be a complex Hilbert space with conjugation operator J. We study J-real operators and we have covered J-regular subspaces. We prove that for given bounded idempotent p there exists a conjugation operator J0 such that p is a J0-projection, i.e.
Matvejchuk M.
core
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Crossing and Setting of Hybrid Seeds in the Creation of Chromosome-Substituted Cotton Lines g. Hirsutum l. [PDF]
BIO Web of ConferencesA comparative study of the indicators of crossability and setting of hybrid and backcross seeds F1, F1BC1, F1BC2, obtained from crossings of monosomic and monotelodisomic lines of cotton G.hirsutum L.
Sanamyan Marina, Bobokhujayev Shukhrat
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Journal of Low Frequency Noise, Vibration and Active ControlThe research on sound source identification in an infinite free sound field has been relatively in-depth, but there is relatively little research on sound source identification and localization in limited spaces, especially those with sound absorption ...
Song Liu +6 more
doaj +1 more source
Modified Linear Peptides Effectively Silence STAT-3 in Breast Cancer and Ovarian Cancer Cell Lines
Pharmaceutics, 2023 RNA interference (RNAi) has drawn enormous attention as a powerful tool because of its capability to interfere with mRNA and protein production. However, designing a safe and efficient delivery system in RNAi therapeutics remains challenging.
Dindyal Mandal +6 more
doaj +1 more source