Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Branch and Bound Algorithm for a Discrete Multilevel Linear Fractional Programming Problem
Operations Research and Decisions, 2018 An algorithm is proposed to find an integer solution for bilevel linear fractional programming problem with discrete variables. The method develops a cut that removes the integer solutions which are not bilevel feasible.
Ritu Arora, Kavita Gupta
doaj
Fuzzy linear fractional programming problem using the lexicography method
Vojnotehnički GlasnikIntroduction/purpose: In solving real-life fractional programming problems, uncertainty and hesitation are often encountered due to various uncontrollable factors.
Sivakumar Karthick +2 more
doaj +1 more source
An exact method for a discrete multiobjective linear fractional optimization [PDF]
Integer linear fractional programming problem with multiple objective MOILFP is an important field of research and has not received as much attention as did multiple objective linear fractional programming.
Chergui, M. E-A, Moulai, M.
core +1 more source
General parametric linear fractional programming
Metrika, 1972 This paper deals with the behaviour of solutions to a linear fractional programming problem when the coefficients of the objective function are allowed to vary.
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Fractional CCP: A Fuzzy Goal Programming Approach
International Journal of Industrial Engineering and Production Research, 2014 It is the purpose of this article to introduce a linear approximation technique for solving a fractional chance constrained programming (CC) problem. For this purpose, a fuzzy goal programming model of the equivalent deterministic form of the fractional ...
Yahia Zare Mehrjerdi
doaj
Some approaches to solving fuzzy linear fractional programming
Wasit Journal of Computer and Mathematics ScienceAn important planning tool is linear fuzzy fractional programming, it is used in various fields such as business, engineering, and others. We are trying to get one of the direct and effective methods that contain some arithmetic operations to obtain the
Waleed Mohammed Elaibi Elaibi +1 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
FINANCIAL STRUCTURE OPTIMIZATION BY USING A GOAL PROGRAMMING APPROACH
Croatian Operational Research Review, 2012 This paper proposes a new methodology for solving the multiple objective fractional linear programming problems using Taylor’s formula and goal programming techniques.
Tunjo Perić, Zoran Babić
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