Results 91 to 100 of about 428,756 (295)

Construction of Liapunov functionals for linear Volterra integrodifferential equations and stability of delay systems

Electronic Journal of Qualitative Theory of Differential Equations, 2000
Inspired by the construction of a new Liapunov functional for linear Volterra integrodifferential equations, we prove some general stability theorems for functional differential equations with infinite delay and weaken the usual requirement for positive ...
Bo Zhang
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

On Nonseparated Three-Point Boundary Value Problems for Linear Functional Differential Equations

Abstract and Applied Analysis, 2011
For a system of linear functional differential equations, we consider a three-point problem with nonseparated boundary conditions determined by singular matrices.
A. Rontó, M. Rontó
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

New Oscillation Criteria for Second-Order Forced Quasilinear Functional Differential Equations

Abstract and Applied Analysis, 2013
We establish some new interval oscillation criteria for a general class of second-order forced quasilinear functional differential equations with ϕ-Laplacian operator and mixed nonlinearities.
Mervan Pašić
doaj   +1 more source

On some boundary value problems for systems of linear functional differential equations

Electronic Journal of Qualitative Theory of Differential Equations, 1999
In this paper on the segment $I=[a,b]$ we will consider the system of linear functional differential equations \begin{equation*}\tag{1} x'_i(t)=\sum\limits_{k=1}^n\ell_{ik}(x_k)(t)+q_i(t)\qquad (i=1,\dots,n) \end{equation*} and its particular case \begin{
Robert Hakl
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Oscillatory behavior in linear retarded functional differential equations

Journal of Mathematical Analysis and Applications, 1987
The purpose of this paper is to investigate oscillatory properties for linear retarded functional differential systems \(\dot x(t)=\int^{0}_{-r}[d\eta (\theta)]x(t+\theta)\) and linear differential-difference system \(\dot x(t)=A_ 0x(t)+\sum^{p}_{j=1}A_ jx(t-r_ j).\) Conditions are obtained when all solutions of autonomous and nonautonomous functional ...
Ferreira, JoséM., Györi, I.
openaire   +1 more source