Results 81 to 90 of about 428,756 (295)

Linear functional-differential equations with abstract Volterra operators

Differential and Integral Equations, 1995
The author develops the basic \(L^p\)-theory of linear functional differential equations with abstract Volterra operator, i.e. \(\dot x(t)= (Lx)(t)+ f(t)\) on \(\mathbb{R}_+\), under initial condition \(x(0)= x^0\in \mathbb{R}^n\). The operator \(L\) is acting continuously on the space \(L^p(\mathbb{R}_+, \mathbb{R}^n)\), and it is assumed linear.
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Computational methods and dynamical analysis for studying ( 1 + 1 ) $(1 + 1)$ dimensional functional equations of mixed integro-differential type

Boundary Value Problems
In the present paper, the Fibonacci collocation method is implemented to solve ( 1 + 1 ) $(1 + 1)$ dimensional difference equations of mixed integro-differential type.
Amr M. S. Mahdy, Mohamed A. Abdou, Doaa S. Mohamed   +2 more
doaj   +1 more source

Pontryagin principle for a Mayer problem governed by a delay functional differential equation

, 2016
We establish Pontryagin principles for a Mayer's optimal control problem governed by a functional differential equation. The control functions are piecewise continuous and the state functions are piecewise continuously differentiable.
Blot, Joël, Kon\', Mamadou Ibrahima
core   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Linear Hyperbolic Functional-Differential Equations with Essentially Bounded Right-Hand Side

Abstract and Applied Analysis, 2011
Theorems on the unique solvability and nonnegativity of solutions to the characteristic initial value problem u1,1(t,x)=l0(u)(t,x)+l1(u1,0)(t,x)+l2(u0,1)(t,x)+q(t,x),   u(t,c)=α(t) for t∈[a,b],  u(a,x)=β(x)  for  x∈[c,d] given on ...
Alexander Domoshnitsky, Alexander Lomtatidze, Abraham Maghakyan, Jiří Šremr   +3 more
doaj   +1 more source

Representations for solutions of linear functional differential equations [PDF]

Representations for solutions of linear functional differential ...
Banks, H. T.
core   +1 more source

Derivative Expansion of the Exact Renormalization Group

, 1994
The functional flow equations for the Legendre effective action, with respect to changes in a smooth cutoff, are approximated by a derivative expansion; no other approximation is made.
Hasenfratz, Margaritis, Polchinski, Tim R. Morris, Wegner, Wegner, Wilson, Zinn-Justin   +7 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Instability of Non-Linear Functional Differential Equations of Fifth Order

Journal of Mathematical and Fundamental Sciences, 2014
In this paper, we study the instability properties of solutions of a kind of functional differential equations of the fifth order with constant delay. Using the Lyapunov-Krasovskii functional approach, we obtain certain sufficient conditions to guarantee
Cemil Tunc
doaj