Results 81 to 90 of about 2,479,210 (291)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Lifting Coalgebra Modalities and $\mathsf{MELL}$ Model Structure to Eilenberg-Moore Categories

open access: yes, 2019
A categorical model of the multiplicative and exponential fragments of intuitionistic linear logic ($\mathsf{MELL}$), known as a \emph{linear category}, is a symmetric monoidal closed category with a monoidal coalgebra modality (also known as a linear ...
Lemay, Jean-Simon Pacaud
core   +1 more source

Linear Mixed Models: Part I

open access: yes, 2021
The best way to understand a linear mixed model, or mixed linear model in some earlier literature, is to first recall a linear regression model. The latter can be expressed as y = Xβ + 𝜖, where y is a vector of observations, X is a matrix of known covariates, β is a vector of unknown regression coefficients, and 𝜖 is a vector of (unobservable random ...
Jiming Jiang, Thuan Nguyen
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Correction: Quantifier spreading: Children misled by ostensive cues

open access: yesGlossa, 2019
This article details a correction to the article É. Kiss, Katalin & Tamás Zétényi. 2017. Quantifier spreading: children misled by ostensive cues. Glossa: A Journal of General Linguistics 2(1). 38.
Katalin É. Kiss   +2 more
doaj   +2 more sources

Warm stellar matter with deconfinement: application to compact stars

open access: yes, 2003
We investigate the properties of mixed stars formed by hadronic and quark matter in $\beta$-equilibrium described by appropriate equations of state (EOS) in the framework of relativistic mean-field theory.
A. Burrows   +49 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Experimental Effects and Individual Differences in Linear Mixed Models: Estimating the Relation of Spatial, Object, and Attraction Effects in Visual Attention

open access: yesFrontiers in Psychology, 2011
Linear mixed models (LMMs) provide a still underused methodological perspective on combining experimental and individual-differences research. Here we illustrate this approach with two-rectangle cueing in visual attention (Egly, Driver, & Rafal, 1994)
Reinhold Kliegl   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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