Results 91 to 100 of about 2,479,210 (291)
Profiled deviance for the multivariate linear mixed-effects model fitting
, 2017 This paper focuses on the multivariate linear mixed-effects model, including all the correlations between the random effects when the marginal residual terms are assumed uncorrelated and homoscedastic with possibly different standard deviations.
Adjakossa, Eric, Nuel, Grégory
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Sample size calculation in multi-centre clinical trials
BMC Medical Research Methodology, 2018 Background Multi-centre randomized controlled clinical trials play an important role in modern evidence-based medicine. Advantages of collecting data from more than one site are numerous, including accelerated recruitment and increased generalisability ...
Markus Harden, Tim Friede
doaj +1 more source
Mixed semi-Lagrangian/finite difference methods for plasma simulations [PDF]
, 2014 In this paper, we present an efficient algorithm for the long time behavior of plasma simulations. We will focus on 4D drift-kinetic model, where the plasma's motion occurs in the plane perpendicular to the magnetic field and can be governed by the 2D ...
Filbet, Francis, Yang, Chang
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
International Journal of Preventive Medicine, 2014 Background: Growth is one of the most important indices in child health. The best and most effective way to investigate child health is measuring the physical growth indices such as weight, height and head circumference.
Sayed-Mohsen Hosseini +3 more
doaj
Ekonometria, 2020 The problem of small area prediction is considered under a Linear Mixed Model. The article presents a proposal of an empirical best linear unbiased predictor under a model with two correlated random effects.
Małgorzata K. Krzciuk
doaj
Mixed oligopoly and spatial agglomeration in quasi-linear city [PDF]
We apply a spatial model that includes both circular-city and linear-city models as special cases to the analysis of location-quantity model in mixed oligopoly.
Daisuke Shimizu +2 more
core
Robust linear functional mixed models
Journal of Multivariate Analysis, 2015 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Marco Riquelme +2 more
openaire +2 more sources