Results 91 to 100 of about 1,982,495 (283)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Precise asymptotics for linear mixed models with crossed random effects
Statistical Theory and Related FieldsWe obtain an asymptotic normality result that reveals the precise asymptotic behaviour of the maximum likelihood estimators of parameters for a very general class of linear mixed models containing cross random effects.
Jiming Jiang +2 more
doaj +1 more source
Linear Quantile Mixed Models: The lqmm Package for Laplace Quantile Regression
Journal of Statistical Software, 2014 Inference in quantile analysis has received considerable attention in the recent years. Linear quantile mixed models (Geraci and Bottai 2014) represent a ?exible statistical tool to analyze data from sampling designs such as multilevel, spatial, panel or
Marco Geraci
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
ON THE ESTIMATION AND PREDICTION IN MIXED LINEAR MODELS
Scientia Agricola, 1998 Beginning with the classical Gauss-Markov Linear Model for mixed effects and using the technique of the Lagrange multipliers to obtain an alternative method for the estimation of linear predictors. A structural method is also discussed in order to obtain
LÓPEZ L.A., IEMMA A.F.
doaj
Forecasting interest rates: A Comparative assessment of some second generation non-linear model [PDF]
Modelling and forecasting of interest rates has traditionally proceeded in the framework of linear stationary models such as ARMA and VAR, but only with moderate success.
Dilip M. Nachane, Jose G. Clavel
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FORECASTING INTEREST RATES - A COMPARATIVE ASSESSMENT OF SOME SECOND GENERATION NON-LINEAR MODELS [PDF]
Modelling and forecasting of interest rates has traditionally proceeded in the framework of linear stationary models such as ARMA and VAR, but only with moderate success.
Dilip M. Nachane, Jose G. Clavel
core +1 more source
Small area estimation for spatially correlated populations - a comparison of direct and indirect model-based methods [PDF]
, 2007 Linear mixed models underpin many small area estimation (SAE) methods. In this paper we investigate SAE based on linear models with spatially correlated small area effects where the neighbourhood structure is described by a contiguity matrix. Such models
Chambers, Ray +2 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source