Results 81 to 90 of about 2,001,852 (330)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Revista Colombiana de Estadística, 2007 The mixed linear model is characterized using the classic linear model of Gauss-Markov. The multipliers of Lagrange are a tool to obtain the best lineal predictors (BLUP), we shown the results of Searle (1997), where some sums of the best linear unbiased
López Luis Alberto +2 more
doaj
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Macro vs. Micro Methods in Non-Life Claims Reserving (an Econometric Perspective)
Risks, 2016 Traditionally, actuaries have used run-off triangles to estimate reserve (“macro” models, on aggregated data). However, it is possible to model payments related to individual claims. If those models provide similar estimations, we investigate uncertainty
Arthur Charpentier, Mathieu Pigeon
doaj +1 more source
Henderson's method approach to Kernel prediction in partially linear mixed models
Cumhuriyet Science Journal, 2020 In this article, we propose Kernel prediction in partially linear mixed models by using Henderson's method approach. We derive the Kernel estimator and the Kernel predictor via the mixed model equations (MMEs) of Henderson's that they give the best ...
Seçil Yalaz, Özge Kuran
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Sobre la construcción del mejor predictor lineal insesgado (BLUP) y restricciones asociadas
Revista Colombiana de Estadística, 2007 A través del modelo lineal clásico de Gauss-Markov, se caracteriza el modelo de efectos mixtos, se aplica la técnica de multiplicadores de Lagrange para obtener los mejores predictores lineales (BLUP) y se ilustran los resultados de Searle (1997), donde ...
LUIS ALBERTO LÓPEZ +2 more
doaj
, 2021 The best way to understand a linear mixed model, or mixed linear model in some earlier literature, is to first recall a linear regression model. The latter can be expressed as y = Xβ + 𝜖, where y is a vector of observations, X is a matrix of known covariates, β is a vector of unknown regression coefficients, and 𝜖 is a vector of (unobservable random ...
Jiming Jiang, Thuan Nguyen
openaire +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Sex-stratified linear mixed models: Non-binary traits (Item 3/3)
, 2021 Elena Bernabeu +3 more
openalex +1 more source