Results 71 to 80 of about 658,808 (305)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Linguistic pitch analysis using functional principal component mixed effect models [PDF]

, 2009
Fundamental frequency (F0, broadly 'pitch') is an integral part of spoken human language; however, a comprehensive quantitative model for F0 can be a challenge to formulate owing to the large number of effects and interactions between effects that lie ...
Aston, John A. D., John A. D. Aston, Chiou, Jeng-Min, Jeng-Min Chiou, Jonathan P. Evans, Evans, Jonathan   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An efficient computing strategy for prediction in mixed linear models [PDF]

, 2004
After estimation of effects from a linear mixed model, it is often useful to form predicted values for certain factor/variate combinations. This process has been well-defined for linear models, but the introduction of random effects means that a decision
Gogel, Beverley, Gogel, B., Thompson, Robin, Welham, Sue, Gilmour, A., Cullis, Brian R., Gilmour, Arthur, Welham, S. J., Thompson, R., Cullis, B. R.   +9 more
core   +1 more source

Penalized Composite Likelihood Estimation for Spatial Generalized Linear Mixed Models [PDF]

Journal of Sciences, Islamic Republic of Iran
When discussing non-Gaussian spatially correlated variables, generalized linear mixed models have enough flexibility for modeling various data types. However, the maximum likelihood methods are plagued with substantial calculations for large data sets ...
Mohsen Mohammadzadeh, Leyla Salehi
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Case-Deletion Diagnostics for Linear Mixed Models [PDF]

Technometrics, 2014
Based on the Q-function, the conditional expectation of the logarithm of the joint-likelihood between responses and random effects, we propose a case-deletion approach to identify influential subjects and influential observations in linear mixed models.
Pan, Jianxin, Fei, Yu, Foster, Peter
openaire   +4 more sources

Genetic heterogeneity of residual variance - estimation of variance components using double hierarchical generalized linear models

, 2010
Background The sensitivity to microenvironmental changes varies among animals and may be under genetic control. It is essential to take this element into account when aiming at breeding robust farm animals.
Erling Strandberg, Rönnegård, Lars, Mulder, Herman A., Felleki Majbritt, Fikse, Freddy, Rönnegård Lars, Majbritt Felleki, Ronnegard, L., Fikse Freddy, Felleki, M., Lars Rönnegård, Freddy Fikse, Herman A Mulder, Strandberg Erling, Mulder, H.A., Strandberg, Erling, Fikse, F., Felleki, Majbritt, Mulder Herman A, Strandberg, E., Rönnegård, Lars,, Felleki, Majbritt,   +21 more
core   +1 more source