Results 91 to 100 of about 2,001,852 (330)

Modeling birth registration in Savannah Region using Linear Mixed Effects Model [PDF]

, 2023
Fatawu Issah, Jakperik Dioggban
openalex   +1 more source

Global and local distance-based generalized linear models [PDF]

, 2016
This paper introduces local distance-based generalized linear models. These models extend (weighted) distance-based linear models first to the generalized linear model framework. Then, a nonparametric version of these models is proposed by means of local
Boj, Eva, Caballé, Adrià, Delicado Useros, Pedro Francisco, Esteve, Anna, Fortiana, Josep   +4 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Congruency of Separable Affix Verb Combinations Is Linearly Indexed by the N400

Frontiers in Human Neuroscience, 2018
Separable affix verbs consist of a stem and a derivational affix, which, in some languages can appear together or in discontinuous, distributed form, e.g., German “aufgreifen” and “greifen … auf” [“up-pick(ing)” and “pick … up”].
Jeff Hanna, Jeff Hanna, Friedemann Pulvermüller, Friedemann Pulvermüller   +3 more
doaj   +1 more source

A stochastic variational framework for fitting and diagnosing generalized linear mixed models

, 2014
In stochastic variational inference, the variational Bayes objective function is optimized using stochastic gradient approximation, where gradients computed on small random subsets of data are used to approximate the true gradient over the whole data set.
Nott, David J., Tan, Linda S. L.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Sensory analysis of Prato cheeses by generalized linear mixed models

Revista do Instituto de Latícinios Cândido Tostes
Sensory analysis, an area of Food Science, is used to analyze and measure characteristics of foods, being able to evaluate the acceptance of samples. Such assessments can be performed using the 9-point numerical hedonic scale, classified as an ordinal ...
Tatiane Carvalho Alvarenga, Jéssica Ferreira Rodrigues   +1 more
doaj   +1 more source

A general approach to mixed effects modeling of residual variances in generalized linear mixed models

Genetics Selection Evolution, 2005
We propose a general Bayesian approach to heteroskedastic error modeling for generalized linear mixed models (GLMM) in which linked functions of conditional means and residual variances are specified as separate linear combinations of fixed and random ...
Kizilkaya Kadir, Tempelman Robert J
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source