Results 61 to 70 of about 3,822,020 (321)
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Identifying genetically driven clinical phenotypes using linear mixed models
Nature Communications, 2016 Use of general linear mixed models (GLMMs) in genetic variance analysis can quantify the relative contribution of additive effects from genetic variation on a given trait.
Jonathan D. Mosley +13 more
doaj +1 more source
Modeling Multiple Item Context Effects With Generalized Linear Mixed Models
Frontiers in Psychology, 2019 Item context effects refer to the impact of features of a test on an examinee's item responses. These effects cannot be explained by the abilities measured by the test. Investigations typically focus on only a single type of item context effects, such as
Norman Rose +6 more
doaj +1 more source
Spatial Autoregressive Modeling on Linear Mixed Models for Dependency Between Regions
Aceh International Journal of Science and Technology, 2023 This study develops a linear mixed model (LMM) that includes spatial effects between regions with a spatial autoregressive model (SAR model). Between observations (regions) on that LMM are usually assumed to be independent. However, these assumptions are
Timbang Sirait
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Linear quantile mixed models [PDF]
, 2011 Dependent data arise in many studies. For example, children with the same parents or living in neighbouring geographic areas tend to be more alike in many characteristics than individuals chosen at random from the population at large; observations taken ...
Bottai, M, Geraci, M
core
Improved testing inference in mixed linear models
, 2009 Mixed linear models are commonly used in repeated measures studies. They account for the dependence amongst observations obtained from the same experimental unit.
Barndorff-Nielsen +23 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
The Discrete Dantzig Selector: Estimating Sparse Linear Models via Mixed Integer Linear Optimization
, 2017 We propose a novel high-dimensional linear regression estimator: the Discrete Dantzig Selector, which minimizes the number of nonzero regression coefficients subject to a budget on the maximal absolute correlation between the features and residuals ...
Mazumder, Rahul, Radchenko, Peter
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source