Results 51 to 60 of about 68,721,496 (226)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

HYERS-ULAM STABILITY OF FIRST ORDER LINEAR DIFFERENCE OPERATORS ON BANACH SPACE

JOURNAL OF ADVANCES IN MATHEMATICS, 2018
In this work, the Hyers-Ulam stability of first order linear difference operator TP defined by (Tpu)(n) = ∆u(n) - p(n)u(n); is studied on the Banach space X = l∞, where p(n) is a sequence of reals.
Arun Kumar Tripathy, Pragnya Senapati
openaire   +2 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Subdifferential calculus for invariant linear ordered vector space-valued operators and applications [PDF]

JOURNAL OF ADVANCES IN MATHEMATICS, 2016
We give a direct proof of sandwich-type theorems for linear invariant partially ordered vector space operators in the setting of convexity. As consequences, we deduce equivalence results between sandwich, Hahn-Banach, separation and Krein-type extension theorems, Fenchel duality, Farkas and Kuhn-Tucker-type minimization results and subdifferential ...
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

On B † - Splitting of Bounded Linear Operators on Ordered Hilbert space

Abstract We discuss a subclass of a positive splitting called B † −splitting of bounded linear operator over ordered Hilbert spaces. The necessary conditions for the existence of such splitting is discussed by assuming the nonnegativity of Moore-Penrose inverse of operators. We refor-mulate a method to construct B † − splitting.
B. Archana, T. Kurmayya
openaire   +1 more source

Hypersurfaces in pseudo-Euclidean spaces satisfying a linear condition on the linearized operator of a higher order mean curvature

Differential Geometry and its Applications, 2013
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Lucas, Pascual, Ramírez-Ospina, Hector Fabián   +1 more
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Graph spaces of first-order linear partial differential operators

Mathematical Communications, 2009
Symmetric positive systems of first-order linear partial differential equations were introduced by K.O. Friedrichs (1958) in order to treat the equations that change their type, like the equations modelling the transonic fluid flow. Recently, some progress in their understanding has been made by rewriting them in terms of Hilbert spaces, characterising
Antonić, Nenad, Burazin, Krešimir
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source