Results 31 to 40 of about 89,086 (217)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Conjugates, Filters and Quantum Mechanics

, 2019
The Jordan structure of finite-dimensional quantum theory is derived, in a conspicuously easy way, from a few simple postulates concerning abstract probabilistic models (each defined by a set of basic measurements and a convex set of states).
Wilce, Alexander
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Locality in GNS Representations of Deformation Quantization

, 1999
In the framework of deformation quantization we apply the formal GNS construction to find representations of the deformed algebras in pre-Hilbert spaces over $\mathbb C[[\lambda]]$ and establish the notion of local operators in these pre-Hilbert spaces ...
Waldmann, Stefan
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Generalization of entanglement to convex operational theories: Entanglement relative to a subspace of observables

, 2005
We define what it means for a state in a convex cone of states on a space of observables to be generalized-entangled relative to a subspace of the observables, in a general ordered linear spaces framework for operational theories. This extends the notion
A. Wilce, C. D. Batista, C. H. Bennett, E. G. Beltrametti, G. Vidal, Gerardo Ortiz, H. Barnum, H. Barnum, Howard Barnum, I. Namioka, J. E. Humphreys, J. S. Bell, K. Eckert, Lorenza Viola, P. Zanardi, R. Delbourgo, Rolando Somma, W. Dür, W.-M. Zhang   +18 more
core   +1 more source

A note on irreducibility for linear operators on partially ordered finite dimensional vector spaces

Linear Algebra and its Applications, 1976
AbstractMany of the important applications of the Perron-Frobenius theory of nonnegative matrices assume that certain matrices are irreducible. The purpose of this note is to introduce a weaker condition which can be used in place of irreducibility, even in the more general setting of linear operators on a partially ordered finite dimensional vector ...
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Weakly Ordered A-Commutative Partial Groups of Linear Operators Densely Defined on Hilbert Space

Acta Polytechnica, 2013
The notion of a generalized effect algebra is presented as a generalization of effect algebra for an algebraic description of the structure of the set of all positive linear operators densely defined on a Hilbert space with the usual sum of operators. The structure of the set of not only positive linear operators can be described with the notion of a ...
openaire   +3 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source