Results 81 to 90 of about 9,886,421 (293)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
KEY COMPETENCE AS A BASIS FOR INNOVATION PROJECTS MANAGEMENT
Сучасний стан наукових досліджень та технологій в промисловості, 2019 By the implementing an enterprise development program, the existing key competence of the organization may undergo significant changes. Also introducing innovations, you can get not only benefits, but additional problems and even risks.
Lyudmyla Chernova
doaj +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Evaluation of the Acceptable Excise Rate on Palm-oil with Use of Linear Optimization Methods
Управленческое консультирование, 2018 The article is devoted to the actual matter of milk production quality and quantity regulation in circumstances of trade war between Russia and some other countries.
Andrey Arkadyevich Dmitriev
doaj
Information, 2018 This paper aims to propose an innovative approach to group decision making (GDM) with interval-valued intuitionistic fuzzy (IVIF) preference relations (IVIFPRs).
Hua Zhuang
doaj +1 more source
Modification of Non-Linear Constrained Optimization [PDF]
Al-Rafidain Journal of Computer Sciences and Mathematics, 2004 In this paper we have investigated a new initial parameter, the new parameter is to make balance between interior suitable for inequality constrained exterior method (suitable for equality and inequality constrained) for non-linear constrained ...
Ban Mitras
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
A Space Decomposition-Based Deterministic Algorithm for Solving Linear Optimization Problems
Axioms, 2019 This document introduces a method to solve linear optimization problems. The method’s strategy is based on the bounding condition that each constraint exerts over the dimensions of the problem.
Gerardo L. Febres
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
The box assignment problem in log yards
Silva Fennica, 2013 This paper presents an optimization approach to minimizing log yard round wood transportation time for a medium sized hardwood sawmill. The log yard, which has to ensure a smooth raw material supply to the entire production process, is the first ...
Jörn Rathke +2 more
doaj +1 more source