Results 121 to 130 of about 13,562,447 (237)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
On the complexity of the robust stability problem for linear parameter varying systems
Automatica, 1996 The author considers linear parameter varying systems \[ x(k+ 1)= \Biggl(A_0+ \sum^n_{i=1} r_i(k)A_i\Biggr) x(k), \] where \(\{r_i(k)\}\) is a sequence such that \(\| r_i(k)\|_\infty\leq 1\) for each \(i= 1,\dots, n\). The system is said to be stable if for each choice of the sequences \(\{r_i(k)\}\) and each initial condition the solution is bounded ...
openaire +3 more sources
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
A General Algorithm for Simultaneous Estimation of Constant and Randomly-Varying Parameters in Lineal Relations [PDF]
A recursive algorithm for estimating linear models with both constant and time-varying parameters is derived by maximization of a likelihood function.
Alexander H. Sarris
core
Научно-технический вестник информационных технологий, механики и оптикиUnknown constant parameters estimation problem for a nonlinear time-varying system with delayed measurements is considered. The objective of this work is to design an adaptive observer for a nonlinear time-varying system.
A. A. Bobtsov +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Joint state and parameter estimation for discrete-time polytopic linear parameter-varying systems
, 2017 Linear parameter-varying systems are very suitable for modelling nonlinear systems, since well-established methods from the linear-systems domain can be applied.
Donkers, M.C.F. +5 more
core +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Event-triggered control for discrete-time linear parameter-varying systems
, 2016 This paper examines a new event-triggered control design approach for discrete-time linear parameter-varying (LPV) system. To this purpose, a novel event-triggering framework is first introduced for LPV systems to reduce the data transmission of the ...
Meskin, N. +5 more
core +1 more source