Results 131 to 140 of about 168,767 (314)
Special issue on linear parameter varying systems [PDF]
, 2014 This special issue contains six papers on the topic of linear parameter varying systems. The papers consider quite different theoretical problems, although four are related to either fault-detection and fault-isolation or fault-tolerant control.
Andres Marcos +5 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Feedback actions on linear parameter-varying systems [PDF]
, 2019 pág. 69-71mLinear parameter-varying systems are studied by means of geometrical translation of some recent results of algebraic nature dealing with the feedback actions on linear control systems ...
García Fernández, Rosa Marta +1 more
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
A Parameter-Dependent Performance Criterion for Linear Parameter-Varying Systems [PDF]
, 1997 Existing control theory for linear parameter-varying systems uses a uniform-in-the-parameters upper bound (a constant scalar) on the induced-L 2 norm. In this paper, this constant is generalized to a function of the parameters; the performance criterion ...
Lawton H. Lee, Mark Spillman
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Journal of Applied Mathematics, 2013 This paper addresses the robust stability for a class of linear discrete-time stochastic systems with convex polytopic uncertainties. The system to be considered is subject to both interval time-varying delays and convex polytopic type uncertainties ...
P. Niamsup, G. Rajchakit
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Discrete Dynamics in Nature and Society, 2015 We investigate the problem of robust exponential stability analysis for uncertain impulsive switched linear systems with time-varying delays and nonlinear perturbations.
Piyapong Niamsup +2 more
doaj +1 more source