Results 71 to 80 of about 989,620 (282)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Ural Mathematical Journal, 2020 Any simple perturbation in a part of the game whether in the cost function and/or conditions is a big problem because it will require a game re-solution to obtain the perturbed optimal solution.
Yousria A. Aboelnaga, Mai Zidan
doaj +1 more source
On Euclidean designs and the potential energy [PDF]
, 2011 We study Euclidean designs from the viewpoint of the potential energy. For a finite set in Euclidean space, We formulate a linear programming bound for the potential energy by applying harmonic analysis on a sphere.
Miezaki, Tsuyoshi, Tagami, Makoto
core +2 more sources
Efficient Linear Programming Decoding of HDPC Codes
, 2009 We propose several improvements for Linear Programming (LP) decoding algorithms for High Density Parity Check (HDPC) codes. First, we use the automorphism groups of a code to create parity check matrix diversity and to generate valid cuts from redundant ...
Be'ery, Yair, Lifshitz, Asi, Yufit, Alex
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Linear Programming Decoding of Spatially Coupled Codes
, 2013 For a given family of spatially coupled codes, we prove that the LP threshold on the BSC of the graph cover ensemble is the same as the LP threshold on the BSC of the derived spatially coupled ensemble.
Bazzi, Louay +2 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source