Results 91 to 100 of about 4,002,335 (287)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A MICROCOMPUTER LINEAR PROGRAMMING PACKAGE: AN ALTERNATIVE TO MAINFRAMES [PDF]
This paper presents the capabilities and limitations of a microcomputer linear programming package. The solution algorithm is a version of the revised simplex.
Laughlin, David H.
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International Journal of Approximate Reasoning, 2010 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hatem Masri, Fouad Ben Abdelaziz
openaire +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
OPTIMALITY AND SEPARABLE LINEAR PROGRAMMING: AN ADDITIONAL REMINDER [PDF]
The assumed global optimum solution obtained in linear programming is not an assumed characteristic of separable linear programming. Separable programming is non-linear programming and must possess certain sufficient conditions for a global optimum to be
Kilmer, Richard L.
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
An extended branch and bound algorithm for linear bilevel programming [PDF]
, 2006 [Abstract]: For linear Bilevel programming, the branch and bound algorithm is the most successful algorithm to deal with the complementary constraints arising from Kuhn-Tucker conditions.
Shi, Chenggen +3 more
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Outlier detection based on Linear programming
, 2012 Outlier detection is an important step in many data-mining applications. In this paper, we propose an outlier detection mathod based on Linear Programming. The essential idea behind this technique is that two neighbor data points must be normal points or
Gao EY(高恩阳) +3 more
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