Results 101 to 110 of about 4,002,335 (287)
, 2005 The thesis is about linear genetic programming (LGP), a machine learning approach that evolves computer programs as sequences of imperative instructions. Two fundamental differences to the more commontree-based variant (TGP) may be identified. These are the graph-based functional structure of linear genetic programs, on the one hand, and the existence ...
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Aircraft Selection Using Linear Physical Programming
Havacılık ve Uzay Teknolojileri Dergisi, 2019 Selection of the most appropriate aircraft is an important decision affecting the profitability of an airline. This decision requires the consideration of many different criteria including seat capacity, fuel consumption and range.
Mehmet Ali Ilgın
doaj
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Termination of Linear Programs [PDF]
, 2004 We show that termination of a class of linear loop programs is decidable. Linear loop programs are discrete-time linear systems with a loop condition governing termination, that is, a while loop with linear assignments. We relate the termination of such a simple loop, on all initial values, to the eigenvectors corresponding to only the positive real ...
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Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Linear Programming and Integer Linear Programming in Bioinformatics.
, 2015 A wide range of important problems related to bioinformatics and computational biology are optimization problems asking for a solution that minimizes or maximizes a certain objective function. Often, these problems are combinatorial optimization problems that can be formulated as integer linear programs. While for some of these problems polynomial time
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source