Results 81 to 90 of about 1,394,927 (329)

A mixed effect model for bivariate meta-analysis of diagnostic test accuracy studies using a copula representation of the random effects distribution [PDF]

, 2015
Diagnostic test accuracy studies typically report the number of true positives, false positives, true negatives and false negatives. There usually exists a negative association between the number of true positives and true negatives, because studies that
Arends, Aristidis K. Nikoloulopoulos, Brechmann, Chu, Chu, Chu, Chu, Demidenko, Genest, Genest, Genest, Genest, Glas, Hamza, Harbord, Harbord, Heffernan, Hua, Hult, Jackson, Jackson, Joe, Joe, Joe, Joe, Kurowicka, Kuss, Lee, Ma, Mavridis, Mavridis, Nash, Nelsen, Nikoloulopoulos, Nikoloulopoulos, Nikoloulopoulos, Nikoloulopoulos, Nikoloulopoulos, Nikoloulopoulos, Normand, Paul, Reitsma, Riley R, Rutter, Rücker, Sarmanov, Scheidler, Serfling, Shen, Sklar, Stroud, Vuong   +51 more
core   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Enhancing Cardiovascular Risk Prediction: Development of an Advanced Xgboost Model with Hospital-Level Random Effects

Bioengineering
Background: Ensemble tree-based models such as Xgboost are highly prognostic in cardiovascular medicine, as measured by the Clinical Effectiveness Metric (CEM). However, their ability to handle correlated data, such as hospital-level effects, is limited.
Tim Dong, Iyabosola Busola Oronti, Shubhra Sinha, Alberto Freitas, Bing Zhai, Jeremy Chan, Daniel P. Fudulu, Massimo Caputo, Gianni D. Angelini   +8 more
doaj   +1 more source

Parameter Estimation and Change Detection in Linear Regression Models Using Mixed Integer Linear Programming

IFAC Proceedings Volumes, 2009
We present a method for detecting changes and estimating parameters in AR(X) models. The method is based on the assumption of piecewise constant parameters resulting in a sparse structure of their ...
Salehpour, Soheil, Johansson, Andreas, Gustafsson, Thomas   +2 more
openaire   +3 more sources

A Revisit to the Application of Weighted Mixed Regression Estimation in Linear Regression Models with Missing Data [PDF]

, 2001
This paper deals with the application of the weighted mixed regression estimation of the coefficients in a linear model when some values of some of the regressors are missing.
Srivastava, V. K., Toutenburg, Helge
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Location–scale models in ecology and evolution: Heteroscedasticity in continuous, count and proportion data

Methods in Ecology and Evolution
Biological data often violate the assumption of constant variance, yet such heteroscedasticity can reflect meaningful biological processes such as plasticity, canalization or stress responses. Despite this, most models treat variance as statistical noise.
Shinichi Nakagawa, Santiago Ortega, Elena Gazzea, Malgorzata Lagisz, Anna Lenz, Erick Lundgren, Ayumi Mizuno   +6 more
doaj   +1 more source

Using multi-temporal Landsat imagery and linear mixed models for assessing water quality parameters in Río Tercero reservoir (Argentina)

, 2015
The application of remote sensing technology to water quality monitoring has special significance for lake management at regional scales. Many studies have proposed algorithms between Landsat data and in-situ water quality parameters using classical ...
M. Bonansea, María Claudia Rodríguez, L. Pinotti, S. Ferrero   +3 more
semanticscholar   +1 more source