Results 81 to 90 of about 3,487,435 (303)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
quam ... pro doctoralibus in utroque iure honoribus & privilegiis solenniter consequendis, censurae publicae submittet Sigismundus Span, Hauensteinio-Bohem. consiliarius Rutheno-Gräzensis ad diem ... ianuar.
Span, Sigismund
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Relações entre TRABALHO, EDUCAÇÃO e SOCIEDADE: Uma proposta de intervenção pedagógica
, 2019 Convidamos vocês para conhecer uma proposta de intervenção pedagógica, idealizada como instrumento orientativo para o desenvolvimento de um curso de curta duração, direcionado à formação inicial ou
Nunes, Albino de Oliveira +2 more
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 2006 1504-1510A facile synthesis of some novel 5-alkyl-1,2-dihydro-spiro[4H-3, 1-benzoxazine-2,3'[3H]indol]-4,2'-diones, in high yields, has been carried out classically as well as under microwave irradiation in solvent free conditions. Microwave irradiation
Saxena, Anjali +4 more
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Synthesis of chemiluminescent biotinyl naphtho[1,8-de][1,2]diazepine-1,4-diones
, 2006 2512-2522A new chemiluminescent seven membered cyclic peri hydrazide, 6-amino-2,3-dihydronaphtho[1,8-de][1,2]diazepine- 1,4-dione (AH, 4), and five of its biotin conjugates with various spacer groups are synthesized.
Reddy, A Ram, Murthy, N V Krishna
core
On the Quotients of Regular Operators
Universal Journal of Mathematics and Applications, 2019 We give some results about quotients of regular operators on Banach lattices by the linear span of the positive M-weakly and positive L-weakly compact operators.
Erdal Bayram +1 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source