Results 91 to 100 of about 63,394 (292)

The Role Of Link Concordance In Knot Concordance

, 2016
Satellite constructions on a knot can be thought of as taking some strands of a knot and then tying in another knot. Using satellite constructions one can construct many distinct isotopy classes of knots. Pushing this further one can construct distinct concordance classes of knots which preserve some algebraic invariants.
openaire   +2 more sources

Slice-torus Concordance Invariants and Whitehead Doubles of Links [PDF]

Canadian Journal of Mathematics, 2019
AbstractIn this paper we extend the definition of slice-torus invariant to links. We prove a few properties of the newly-defined slice-torus link invariants: the behaviour under crossing change, a slice genus bound, an obstruction to strong sliceness, and a combinatorial bound.
Cavallo A., Collari C.
openaire   +3 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Oxidative Stress: A Link between Diabetes Mellitus and Periodontal Disease

International Journal of Endocrinology, 2014
Objective. To investigate oxidative stress (OS) and histological changes that occur in the periodontium of subjects with type 2 diabetes mellitus without signs of periodontal disease and to establish if oxidative stress is a possible link between ...
Adriana Monea, Tibor Mezei, Sorin Popsor, Monica Monea   +3 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Small molecule in situ resin capture provides a compound first approach to natural product discovery

Nature Communications
Culture-based microbial natural product discovery strategies fail to realize the extraordinary biosynthetic potential detected across earth’s microbiomes.
Alexander Bogdanov, Mariam N. Salib, Alexander B. Chase, Heinz Hammerlindl, Mitchell N. Muskat, Stephanie Luedtke, Elany Barbosa da Silva, Anthony J. O’Donoghue, Lani F. Wu, Steven J. Altschuler, Tadeusz F. Molinski, Paul R. Jensen   +11 more
doaj   +1 more source

Linking the English Cancer Patient Experience Survey to Cancer registration: relating patient experience to outcomes, a step towards better services and outcomes

International Journal of Population Data Science, 2017
Objectives To link the English Cancer Patient Experience Survey (CPES) to Public Health England’s cancer registration records and allow new exploration of the association between patient experience and outcomes and eventually improve service provision ...
Isabella Gomes Carneiro, James Charnock, Anna Fry, Vivian Mak, Nick Ormiston-Smith, Hannah McConnell, Yoryos Lyratzopoulos   +6 more
doaj   +1 more source

Link Concordance and Groups

, 2019
This work concerns the study of link concordance using groups, both extracting concordance data from group theoretic invariants and determining the properties of group structures on links modulo concordance.
Kuzbary, Miriam
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