Results 81 to 90 of about 4,864,620 (366)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Factorization in Phase-Space Finite Geometry and Weak Mutually Unbiased Bases

open access: yesAfrican Scientific Reports, 2023
A phase-space factorization of lines in finite geometry G(m) with variables in Zm and its correspondence in finite Hilbert space H(m) for m a non-prime was discussed. Using the method of Good [15], lines in G(m) were factorized as products of lines G(mi)
A. D. Adeshola   +3 more
doaj   +1 more source

Conceptual Issues for Noncommutative Gravity on Algebras and Finite Sets

open access: yes, 1999
We discuss some of the issues to be addressed in arriving at a definitive noncommutative Riemannian geometry that generalises conventional geometry both to the quantum domain and to the discrete domain.
Majid, S.
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

From Fractal Geometry to Statistical Fractal

open access: yesRecoletos Multidisciplinary Research Journal, 2013
The development from fractal geometry to fractal statistics was established in this paper. Interesting features such as self similarity, scale invariance, and the spacefilling property of objects (fractal dimension) of fractal geometry provided an ...
Roberto N. Padua, Mark S. Borres
doaj   +1 more source

Free factorization algebras and homology of configuration spaces in algebraic geometry

open access: yes, 2017
We provide a construction of free factorization algebras in algebraic geometry and link factorization homology of a scheme with coefficients in a free factorization algebra to the homology of its (unordered) configuration spaces.
Ho, Q. P.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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