Results 101 to 110 of about 537,873 (344)
The Trimmed-Haplotype Test for Linkage Disequilibrium [PDF]
The American Journal of Human Genetics, 2000 Single-marker linkage-disequilibrium (LD) methods cannot fully describe disequilibrium in an entire chromosomal region surrounding a disease allele. With the advent of myriad tightly linked microsatellite markers, we have an opportunity to extend LD analysis from single markers to multiple-marker haplotypes. Haplotype analysis has increased statistical
MacLean, C J +5 more
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Quantitative genetics theory for non-inbred populations in linkage disequilibrium
Genetics and Molecular Biology, 2004 Although linkage disequilibrium, epistasis and inbreeding are common phenomena in genetic systems that control quantitative traits, theory development and analysis are very complex, especially when they are considered together.
José Marcelo Soriano Viana
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Genome Research, 2014 DNA variants (SNPs) that predispose to common traits often localize within noncoding regulatory elements such as enhancers. Moreover, loci identified by genome-wide association studies (GWAS) often contain multiple SNPs in linkage disequilibrium (LD ...
Olivia Corradin +8 more
semanticscholar +1 more source
Genome‐Wide Insights and Polygenic Risk Scores in Common Epilepsies: A Narrative Review
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT The research of single gene‐related disorders or pathogenic copy‐number variations (CNVs) has given a significant impetus to the shift from a diagnostic work‐up focused on epileptic syndromes to genomic approaches in individuals with severe pediatric‐onset epilepsies and in developmental and epileptic encephalopathies.
Mario Mastrangelo +5 more
wiley +1 more source
PLoS ONE, 2014 Understanding the population structure and linkage disequilibrium in an association panel can effectively avoid spurious associations and improve the accuracy in association mapping.
Yunlei Zhao +3 more
semanticscholar +1 more source
Honey Bee Breeding and Breed: Advancements, Challenges, and Prospects
Animal Research and One Health, EarlyView.Our work clarifies concepts related to honey bee classification, reviews traditional and modern breeding techniques, explores advancements in molecular breeding, prospects gene‐editing tools, and advocates for integrated breeding strategies to ensure the long‐term sustainability and vitality of honey bee populations amid declining managed populations ...
Zheguang Lin +5 more
wiley +1 more source
Pairwise Linkage Disequilibrium Estimation for Polyploids [PDF]
Molecular Ecology Resources, 2020 AbstractMany tasks in statistical genetics involve pairwise estimation of linkage disequilibrium (LD). The study of LD in diploids is mature. However, in polyploids, the field lacks a comprehensive characterization of LD. Polyploids also exhibit greater levels of genotype uncertainty than diploids, and yet no methods currently exist to estimate LD in ...
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G3: Genes, Genomes, Genetics, 2017 We explore the effect of different mechanisms of natural selection on the evolution of populations for one- and two-locus systems. We compare the effect of viability and fecundity selection in the context of the Wright-Fisher model with selection under ...
Zhangyi He, Mark Beaumont, Feng Yu
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Characterizing Linkage Disequilibrium in Pig Populations
International Journal of Biological Sciences, 2007 Knowledge of the extent and range of linkage disequilibrium (LD), defined as non-random association of alleles at two or more loci, in animal populations is extremely valuable in localizing genes affecting quantitative traits, identifying chromosomal ...
Feng-Xing Du, Archie C. Clutter, Michael M. Lohuis
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