Results 111 to 120 of about 537,873 (344)

Linkage disequilibrium and haplotype block structure in a composite beef cattle breed

BMC Genomics, 2014
The development of linkage disequilibrium (LD) maps and the characterization of haplotype block structure at the population level are useful parameters for guiding genome wide association (GWA) studies, and for understanding the nature of non-linear ...
F. B. Mokry, M. E. Buzanskas, Mauricio de Alvarenga Mudadu, Daniela do Amaral Grossi, R. H. Higa, R. Ventura, A. O. de Lima, M. Sargolzaei, Sarah Laguna Conceição Meirelles, F. Schenkel, M. V. B. da Silva, Simone Cristina Méo Niciura, M. M. de Alencar, D. P. Munari, Luciana Correia de Almeida Regitano   +14 more
semanticscholar   +1 more source

Linkage disequilibrium interval mapping of quantitative trait loci

BMC Genomics, 2006
Background For many years gene mapping studies have been performed through linkage analyses based on pedigree data. Recently, linkage disequilibrium methods based on unrelated individuals have been advocated as powerful tools to refine estimates of gene ...
de Rochambeau Hubert, Abdallah Jihad, Boitard Simon, Cierco-Ayrolles Christine, Mangin Brigitte   +4 more
doaj   +1 more source

Genetic causal association between heart failure, frailty and poisoning by narcotics and psychodysleptics: A two‐sample Mendelian randomization

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Observational studies have suggested associations between heart failure (HF), frailty and poisoning by narcotics and psychodysleptics (PNP). However, establishing causal relationships has been challenging. This study used a two‐sample Mendelian randomization (MR) approach to investigate the genetically proxied causality between HF ...
Bing Wang, Hong Yu, Meng Cai, Xianqiao Xie   +3 more
wiley   +1 more source

Credibility of genetic predictors for antiepileptic drug resistance: A systematic Bayesian reappraisal of published meta‐analyses

British Journal of Clinical Pharmacology, EarlyView.
We systematically reappraised meta‐analyses of pharmacogenetic studies to evaluate the credibility of association between gene polymorphisms and resistance to anti‐epileptic drugs (AEDs). A systematic search was performed in PubMed, Web of Knowledge, Cochrane Library and OpenGrey up to April 2025.
Martina Giacon, Sarah Cargnin, Salvatore Terrazzino   +2 more
wiley   +1 more source

Variability of Leptin gene promoter in cattle

Italian Journal of Animal Science, 2010
A preliminary analysis on the variability of Leptin gene promoter in seven cattle breeds was carried out, focusing the attention on the SNP at nt 1759, which has been suggested to affect some quantitative traits in cattle.
L. Di Stasio, S. Sartore, C. Lisa
doaj   +1 more source

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

Cancer Communications, EarlyView.
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao, Xiaozhen Zhang, Zejun Li, Kang Sun, Hanshen Yang, Sicheng Wang, Lihong He, Yan Chen, Hanjia Zhang, Jiatao Shi, Daqian Xu, Tingbo Liang, Xueli Bai   +12 more
wiley   +1 more source

Impact of slug length in gas–liquid two‐phase flow on the structural stress characteristics of horizontal rigid pipelines

The Canadian Journal of Chemical Engineering, EarlyView.
Data collection and processing of slug length in two‐phase flow‐induced stress analysis. Abstract The intermittent passage of liquid slugs and gas pockets in slug flow generates substantial cyclic stress damage to piping systems and their supports. This issue poses significant challenges to the various industries in which this flow pattern is present ...
Abdalellah O. Mohmmed, Hussain H. Al‐Kayiem, Abderraouf Arabi   +2 more
wiley   +1 more source

Linkage disequilibrium estimates of contemporary Ne using highly variable genetic markers: a largely untapped resource for applied conservation and evolution

Evolutionary Applications, 2009
Genetic methods are routinely used to estimate contemporary effective population size (Ne) in natural populations, but the vast majority of applications have used only the temporal (two‐sample) method.
R. Waples, C. Do
semanticscholar   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

THE SAMPLING DISTRIBUTION OF LINKAGE DISEQUILIBRIUM [PDF]

Genetics, 1984
ABSTRACT The probabilities of obtaining particular samples of gametes with two completely linked loci are derived. It is assumed that the population consists of N diploid, randomly mating individuals, that each of the two loci mutate according to the infinite allele model at a rate µ and that the population is at equilibrium. When 4Nµ is
openaire   +3 more sources