Results 181 to 190 of about 199,519 (335)

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang, Robert A. Hauser, Lorraine V. Kalia, Bonnie Hersh, Zdenek Berger, Roy Llorens Arenas, Coro Paisan‐Ruiz, Kyle Fraser, Danna Jennings, Jillian H. Kluss, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, J. Timothy Greenamyre   +12 more
wiley   +1 more source

Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids

Movement Disorders, EarlyView.
Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

X-LDR: an atlas of linkage disequilibrium across species. [PDF]

Genome Biol
Zhu TN, Huang X, Yang MY, Qi GA, Zhang QX, Lin F, Zhang W, Zhang Z, Jin X, Zheng HF, Xu HM, Yu S, Chen GB.   +12 more
europepmc   +1 more source

The Linkage-Disequilibrium and Recombinational Landscape in Daphnia pulex. [PDF]

Genome Biol Evol, 2022
Lynch M, Ye Z, Urban L, Maruki T, Wei W.
europepmc   +1 more source

Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study

PM&R, EarlyView.
Abstract Background Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation.
Qiong Wang, Qing Kuang, Cheng Chen, Binru Wang, Wei Xiang, Xinming Li, Jianjiao Mou   +6 more
wiley   +1 more source

Interchromosomal linkage disequilibrium analysis reveals strong indications of sign epistasis in wheat breeding families. [PDF]

G3 (Bethesda)
Tessele A, Morris G, Akhunov E, Johnson B, Clinesmith M, Hope AC, Fritz A.   +6 more
europepmc   +1 more source

Accurate and efficient estimation of local heritability using summary statistics and the linkage disequilibrium matrix. [PDF]

Nat Commun, 2023
Li H, Mazumder R, Lin X.
europepmc   +1 more source

Range‐wide sampling reveals cryptic lineages but largely conserved mycorrhizal associations in the Japanese fairy lantern Thismia kobensis

PLANTS, PEOPLE, PLANET, EarlyView.
The jewel‐like flowers of Thismia are as rare as they are beautiful, often recorded from only a single site per species. Access to 15 populations of T. kobensis has enabled an uncommon, range‐wide assessment of morphology, genetics, and fungal partners. Our analyses showed that T.
Kenji Suetsugu, Kazuma Takizawa, Kazuki Inui, Akihiro Nishimura, Shun K. Hirota   +4 more
wiley   +1 more source

SNPs with High Linkage Disequilibrium Increase the Explained Genetic Variance and the Reliability of Genomic Predictions. [PDF]

Animals (Basel)
Cortes-Hernández JG, Ruiz-López FJ, Peñagaricano F, Montaldo HH, García-Ruiz A.   +4 more
europepmc   +1 more source

Estimating linkage disequilibrium and selection from allele frequency trajectories. [PDF]

Genetics, 2023
Li Y, Barton JP.
europepmc   +1 more source