Results 51 to 60 of about 177,696 (251)
Linkage disequilibrium mapping and tagging in sugarcane : [Abstract W233] [PDF]
, 2009 Linkage disequilibrium (LD) in crops, established by domestication and early breeding, can be a valuable basis for mapping the genome. We have assessed LD in sugarcane (Saccharum spp), characterized by one of the most complex crop genomes, with its high ...
Butterfield, Mike +5 more
core
High genetic diversity at the extreme range edge: nucleotide variation at nuclear loci in Scots pine (Pinus sylvestris L.) in Scotland [PDF]
, 2011 Nucleotide polymorphism at 12 nuclear loci was studied in Scots pine populations across an environmental gradient in Scotland, to evaluate the impacts of demographic history and selection on genetic diversity.
A Karhu +82 more
core +2 more sources
LINKAGE DISEQUILIBRIUM WITH THE ISLAND MODEL [PDF]
Genetics, 1982 ABSTRACT Linkage disequilibrium between two linked loci was studied for a finite population with a subdivided population structure. Wright's island model was used; extinction and replacement of colonies were also incorporated. Two alleles (A 1 and A 2 at the first locus, and B 1 and B 2 at the second locus) with symmetric mutation ...
openaire +2 more sources
Linkage disequilibrium in natural populations of Trypanosoma cruzi (flagellate), the agent of Chagas's disease [PDF]
, 1988 We have studied linkage disequilibrium in natural populations of Trypanosoma cruzi, the agent of Chagas' disease, by analyzing (i) a set of 524 stocks from the whole geographical range of the parasite, characterized at four gene loci coding for enzymes; (
Ayala, F.J. +2 more
core
Arthritis &Rheumatology, EarlyView.Objective The sparse effector “omnigenic” hypothesis postulates that the polygenic effects of common single nucleotide polymorphisms (SNPs) on a typical complex trait are mediated by trans effects that coalesce on expression of a relatively sparse set of core genes.
Athina Spiliopoulou +9 more
wiley +1 more source
High-density SNP association study of the 17q21 chromosomal region linked to autism identifies CACNA1G as a novel candidate gene. [PDF]
, 2009 Chromosome 17q11-q21 is a region of the genome likely to harbor susceptibility to autism (MIM(209850)) based on earlier evidence of linkage to the disorder.
Cantor, RM +6 more
core +3 more sources
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Observational studies have suggested associations between heart failure (HF), frailty and poisoning by narcotics and psychodysleptics (PNP). However, establishing causal relationships has been challenging. This study used a two‐sample Mendelian randomization (MR) approach to investigate the genetically proxied causality between HF ...
Bing Wang +3 more
wiley +1 more source
Genotype determination for polymorphisms in linkage disequilibrium [PDF]
BMC Bioinformatics, 2009 Genome-wide association studies with single nucleotide polymorphisms (SNPs) show great promise to identify genetic determinants of complex human traits. In current analyses, genotype calling and imputation of missing genotypes are usually considered as two separated tasks.
Yu, Zhaoxia +4 more
openaire +5 more sources
Identification and Replication of Three Novel Myopia Common Susceptibility Gene Loci on Chromosome 3q26 using Linkage and Linkage Disequilibrium Mapping [PDF]
, 2008 Refractive error is a highly heritable quantitative trait responsible for considerable morbidity. Following an initial genome-wide linkage study using microsatellite markers, we confirmed evidence for linkage to chromosome 3q26 and then conducted fine ...
Toby Andrew +40 more
core +1 more source
Cancer Communications, EarlyView.Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao +12 more
wiley +1 more source