The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem [PDF]
, 2016 Several important and fundamental aspects of disease genetics models have yet to be described. One such property is the relationship of disease association statistics at a marker site closely linked to a disease causing site.
Bansal, Naveen K. +8 more
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Meta‐GWAS of Pig Semen Quality Traits Reveals Conserved Genes Regulating Mammalian Fertility
Advanced Science, EarlyView.This study incorporated 14 210 individuals to perform a GWAS meta‐analysis of six semen quality traits. The GWAS meta‐analysis identifies 234 GWAS loci associated with semen quality traits. The incorporation with a functional genomics resource explains potential genetic regulation of ∼40% GWAS signals underlying semen quality traits.
Qing Lin +26 more
wiley +1 more source
Genome-wide analysis of zygotic linkage disequilibrium and its components in crossbred cattle
BMC Genetics, 2012 Background Linkage disequilibrium (LD) between genes at linked or independent loci can occur at gametic and zygotic levels known asgametic LD and zygotic LD, respectively. Gametic LD is well known for its roles in fine-scale mapping of quantitative trait
Jiang Qi +3 more
doaj +1 more source
THE DIRECTION OF LINKAGE DISEQUILIBRIUM [PDF]
Genetics, 1974 ABSTRACT The previous paper (LANGLEYT,O BARanId KOJIMA 1974) reports that the directional linkage disequilibria, Dw = PABPab-PAbPaB, tend to be negative for data between allozymes and linked to inversions. A and B stand for the two alleles with the greatest frequency in the population. In this paper we show that linkage disequilibrium in
C H, Langley, J F, Crow
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How to interpret the inference of recombination landscapes on methods based on linkage disequilibrium? [PDF]
, 2023 Sebastián E. Ramos‐Onsins
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Effect of linkage disequilibrium on inferences of population structure and introgression of iberian and black honey bees [PDF]
, 2012 Identification of population structure, a primary goal in population genetics, is easily performed because there is a number of methods available, implemented by user-friendly software packages.
Chávez-Galarza, Julio +6 more
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Advanced Science, EarlyView.This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen +8 more
wiley +1 more source
Identification of Genetic Loci Associated with Quality Traits in Almond via Association Mapping. [PDF]
PLoS ONE, 2015 To design an appropriate association study, we need to understand population structure and the structure of linkage disequilibrium within and among populations as well as in different regions of the genome in an organism.
Carolina Font i Forcada +5 more
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Confounding by linkage disequilibrium [PDF]
Journal of Human Genetics, 2013 Linkage disequilibrium (LD) and confounding are two widely discussed concepts in Genetics and in Epidemiology, yet their relationship has received only intuitive or no considerations. Taken in the narrow sense, LD refers to the nonrandom association of alleles at two or more linked genetic loci.
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Co-selection of the H63D mutation and the HLA-A29 allele: a new paradigm of linkage disequilibrium? [PDF]
, 2002 The major histocompatibility complex (MHC) shows a remarkable conservation of particular HLA antigens and haplotypes in linkage disequilibrium in most human populations, suggesting the existence of a convergent evolution.
Alves, H. +8 more
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