Results 71 to 80 of about 537,873 (344)

Linkage disequilibrium in human populations [PDF]

Proceedings of the National Academy of Sciences, 2003
Whereas the human linkage map appears on limited evidence to be constant over populations, maps of linkage disequilibrium (LD) vary among populations that differ in gene history. The greatest difference is between populations of sub-Saharan origin and populations remotely derived from Africa after a major bottleneck that reduced their ...
Lonjou, Christine, Zhang, Weihua, Collins, Andrew, Tapper, William J., Elahi, Eiram, Maniatis, Nikolas, Morton, Newton E.   +6 more
openaire   +4 more sources

Association mapping for kernel phytosterol content in almond

Frontiers in Plant Science, 2015
Almond kernels are a rich source of phytosterols, which are important compounds for human nutrition. The genetic control of phytosterol content has not yet been documented in almond.
Carolina eFont i Forcada, Leonardo eVelasco, Rafel eSocias i Company, Angel eFernández i Martí   +3 more
doaj   +1 more source

Natural Allelic Variations in IbCHYR1–IbZnFR Complex Regulate Fusarium Root Rot Resistance in Sweet Potato

Advanced Science, EarlyView.
FfRlpA2, a conserved Fusarium effector, functions as a protease inhibitor by hijacking the E3 ubiquitin ligase IbCHYR1 to degrade the resistance factor IbZnFR, thereby promoting Fusarium pathogenicity. Conversely, the high dosage Pro::IbZnFRHap2 allele was associated with resistance to root rot disease.
Huan Zhang, Zhuoru Dai, Xiaochen Zhang, Meiqi Shang, Xiaoru Gao, Ruiqi Ma, Limeng Zhao, Xiaoli Zhang, Qingchang Liu, Hong Zhai, Shaopei Gao, Ning Zhao, Qinghe Cao, Qiang Li, Shaozhen He   +14 more
wiley   +1 more source

A Targeted Capture Linkage Map Anchors the Genome of the Schistosomiasis Vector Snail, Biomphalaria glabrata

G3: Genes, Genomes, Genetics, 2017
The aquatic planorbid snail Biomphalaria glabrata is one of the most intensively-studied mollusks due to its role in the transmission of schistosomiasis. Its 916 Mb genome has recently been sequenced and annotated, but it remains poorly assembled.
Jacob A. Tennessen, Stephanie R. Bollmann, Michael S. Blouin   +2 more
doaj   +1 more source

Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium.

American Journal of Human Genetics, 2004
Common genetic polymorphisms may explain a portion of the heritable risk for common diseases. Within candidate genes, the number of common polymorphisms is finite, but direct assay of all existing common polymorphism is inefficient, because genotypes at ...
C. Carlson, M. Eberle, M. Rieder, Q. Yi, L. Kruglyak, D. Nickerson   +5 more
semanticscholar   +1 more source

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

Advanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao, Huanhuan Cao, Meifang Wu, Zhihuang Qiu, Yuling Zhang, Yue Shen, Qiuyu Huang, Zhiyong Lin, Lemin Zheng, Liangwan Chen   +18 more
wiley   +1 more source

Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa

Advanced Science, EarlyView.
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang, Xiaofei Wang, Chengli Liu, Kaixuan He, Xiu‐Li Hou, Haofei Luo, Shuaibin Zhang, Changqing You, Yajun Jia, Fuqiang Wang, Xianwei Song, Guodao Liu, Xian Deng, Xiaofeng Cao   +13 more
wiley   +1 more source

Linkage disequilibrium network analysis (LDna) gives a global view of chromosomal inversions, local adaptation and geographic structure

Molecular Ecology Resources, 2015
Recent advances in sequencing allow population‐genomic data to be generated for virtually any species. However, approaches to analyse such data lag behind the ability to generate it, particularly in nonmodel species.
P. Kemppainen, C. Knight, D. Sarma, T. Hlaing, A. Prakash, Yan Naung Maung Maung, P. Somboon, J. Mahanta, C. Walton   +8 more
semanticscholar   +1 more source

A Genealogical Interpretation of Linkage Disequilibrium [PDF]

Genetics, 2002
Abstract The degree of association between alleles at different loci, or linkage disequilibrium, is widely used to infer details of evolutionary processes. Here I explore how associations between alleles relate to properties of the underlying genealogy of sequences.
openaire   +4 more sources

Characterization of linkage disequilibrium, consistency of gametic phase and admixture in Australian and Canadian goats

BMC Genetics, 2015
BackgroundBasic understanding of linkage disequilibrium (LD) and population structure, as well as the consistency of gametic phase across breeds is crucial for genome-wide association studies and successful implementation of genomic selection.
L. Brito, M. Jafarikia, D. Grossi, J. Kijas, L. Porto-Neto, R. Ventura, Mehdi Salgorzaei, F. Schenkel   +7 more
semanticscholar   +1 more source