Results 121 to 130 of about 137,248 (162)

Linkage Maps of Human Genes

Pediatrics International, 1987
AbstractMethodologies and tools for the construction of complete, primary genetic linkage maps of human chromosomes are emerging. Special families, optimal because of family structure for revealing linkage relationships, have been sampled and a number of genotypic determinations gathered.
R, White, M, Leppert, P, O'Connell, Y, Nakamura, T, Holm, G M, Lathrop, J M, Lalouel   +6 more
openaire   +2 more sources

A Genetic Linkage Map for the Zebrafish

Science, 1994
To facilitate molecular genetic analysis of vertebrate development, haploid genetics was used to construct a recombination map for the zebrafish Danio ( Brachydanio ) rerio .
John H. Postlethwait, Stephen L. Johnson, Clare N. Midson, William S. Talbot, Michael Gates, Eric W. Ballinger, Dana Africa, Rebecca Andrews, Tim Carl, Judith S. Eisen, Sally Horne, Charles B. Kimmel, Mark Hutchinson, Michele Johnson, Andre Rodriguez   +14 more
openaire   +2 more sources

Linkage maps of human chromosomes

Genome, 1989
Finding the chromosomal location of human genes that heretofore have been defined solely by phenotypes, in particular clinical phenotypes that are transmitted in Mendelian fashion in families, is an early and often crucial step in the process of identifying the molecular basis of a disease.
R, White, J M, Lalouel, M, Leppert, M, Lathrop, Y, Nakamura, P, O'Connell   +5 more
openaire   +2 more sources

Novel approaches to linkage mapping

Current Opinion in Genetics & Development, 1995
The recent progress seen in the development of high-quality genetic markers and high-density human genetic maps is facilitating new strategies for mapping disease-causing and disease-susceptibility genes. These strategies, which include homozygosity mapping, DNA pooling, and the utilization of linkage disequilibrium, have been successfully applied to ...
V C, Sheffield, D Y, Nishimura, E M, Stone   +2 more
openaire   +2 more sources

RFLP linkage map of asparagus

Genome, 1996
A population resulting from a double pseudotestcross of two outbred-derived asparagus (Asparagus officinalis L.) clones was evaluated by RFLP (restriction fragment length polymorphism) analysis to produce individual maps of the male and female parents. An asparagus PstI genomic library was created and used as the source of probes.
M E, Lewis, K C, Sink
openaire   +2 more sources

Combined linkage and linkage disequilibrium mapping for genome screens

Genetic Epidemiology, 2000
Linkage analysis and association studies, two major approaches for genetic studies of human diseases, are useful for mapping genes that are highly penetrant, but both use only part of the information that is available for mapping disease genes. Therefore, they provide limited utility when used alone.
Li Jin, Momiao Xiong
exaly   +3 more sources

LINKAGE MAP IN KIWIFRUIT: THE CHOICE OF MAPPING POPULATIONS

Acta Horticulturae, 2003
A genetic map of kiwifruit (Actinidia spp.) was constructed using microsatellite and AFLP markers and the pseudo-test-cross mapping strategy. Some 105 microsatellite loci, of the 251 isolated from A. chinensis, segregated in the interspecific cross A. chinensis x A. callosa in a 1:1 ratio or in a ratio that could mimic the classical backcross, and were
TESTOLIN, Raffaele, DI GASPERO, Gabriele, HUANG WG, CIPRIANI, Guido, LAIN, Orietta, MESSINA, Rachele   +5 more
openaire   +2 more sources

Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes

Biological Psychology, 2002
Linkage analyses of highly heritable electrophysiological phenotypes (EEG, ERP) that can potentially identify individuals at risk for alcoholism were performed on a large sample of families with a high density of alcohol dependence as part of the Collaborative Study on the Genetics of Alcoholism (COGA); these genetic findings are summarized ...
Bernice, Porjesz, Henri, Begleiter, Kongming, Wang, Laura, Almasy, David B, Chorlian, Arthur T, Stimus, Samuel, Kuperman, Sean J, O'Connor, John, Rohrbaugh, Lance O, Bauer, Howard J, Edenberg, Alison, Goate, John P, Rice, Theodore, Reich   +13 more
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Linkage Disequilibrium and Association Mapping

Annual Review of Genomics and Human Genetics, 2008
Linkage disequilibrium refers to the association between alleles at different loci. The standard definition applies to two alleles in the same gamete, and it can be regarded as the covariance of indicator variables for the states of those two alleles. The corresponding correlation coefficient ρ is the parameter that arises naturally in discussions of ...
openaire   +2 more sources

Bayesian Multilocus Linkage Mapping

1988
The construction of mammalian genetic maps entails finding solutions to a number of distinct but interrelated problems. First, linkage to the correct chromosome and chromosomal region must be established, and linkage to other chromosomal regions must be excluded.
R D, Blank, G R, Campbell, M, Pollak, P, D'Eustachio   +3 more
openaire   +2 more sources