Results 21 to 30 of about 4,098,264 (291)

LINKER: a program to generate linker sequences for fusion proteins [PDF]

open access: yesProtein Engineering, Design and Selection, 2000
The construction of functional fusion proteins often requires a linker sequence that adopts an extended conformation to allow for maximal flexibility. Linker sequences are generally selected based on intuition. Without a reliable selection criterion, the design of such linkers is often difficult, particularly in situations where longer linker sequences
Chiquito J. Crasto, Jin An Feng
openaire   +3 more sources

Progresses in research and development of antibody-drug conjugate

open access: yes生物医学转化, 2021
Through referring to the literature and related databases, the research process of antibodyconjugated drugs was reviewed, and the key elements of ADC were summarized.
Wu Gang   +6 more
doaj   +1 more source

The Linker Region Promotes Activity and Binding Efficiency of Modular LPMO towards Polymeric Substrate

open access: yesMicrobiology Spectrum, 2022
Lytic polysaccharide monooxygenases (LPMOs) mediate oxidative degradation of plant polysaccharides. The genes encoding LPMOs are most commonly arranged with one catalytic domain, while a few are found tethered to additional noncatalytic units, i.e ...
Aishwarya Srivastava   +3 more
doaj   +1 more source

Precise Control of Molecular Self-Diffusion in Isoreticular and Multivariate Metal-Organic Frameworks. [PDF]

open access: yes, 2020
Understanding the factors that affect self-diffusion in isoreticular and multivariate (MTV) MOFs is key to their application in drug delivery, separations, and heterogeneous catalysis.
Osborn Popp, Thomas M   +3 more
core   +2 more sources

Optimal number of linkers per monomer in linker-mediated aggregation [PDF]

open access: yesSoft Matter, 2019
We study the dynamics of diffusion-limited irreversible aggregation of monomers, where bonds are mediated by linkers.
G. C. Antunes   +3 more
openaire   +4 more sources

Arginine 37 of Glycine Linker Dictates Regulatory Function of HapR

open access: yesFrontiers in Microbiology, 2020
HapR is designated as a high cell density quorum sensing master regulatory protein of Vibrio cholerae. It is a member of the TetR family protein and functions both as an activator and a repressor by directly communicating with cognate promoters, thus ...
Manjula Ekka   +5 more
doaj   +1 more source

Strategies for Expressing Possession in Some Iranian Linguistic Varieties [PDF]

open access: yesمطالعات زبان‌‌ها و گویش‌های غرب ایران, 2019
The present study aims at reviewing the strategies employed in some Iranian linguistic varieties in order to express possession. To do so, first the type of possessive strategy used in each variety was described based upon the categorization made by ...
Shahla Sharifi, Narjes Banoo Sabouri
doaj   +1 more source

Development of applicable thiol-linked antibody–drug conjugates with improved stability and therapeutic index

open access: yesDrug Delivery, 2022
Maleimides are typically applicable for coupling with reactive thiol moieties of antibodies in antibody–drug conjugates (ADCs) via the thiol-Michael click chemistry.
Yanming Wang   +6 more
doaj   +1 more source

A Kinetic Model for the Enzymatic Action of Cellulase [PDF]

open access: yes, 2009
We develop a mechanochemical model for the dynamics of cellulase, a two-domain enzyme connected by a peptide linker, as it extracts and hydrolyzes a cellulose polymer from a crystalline substrate.
Makarov, Dmitrii E.   +2 more
core   +2 more sources

Docking of a Linker Histone to The Nucleosome With Flexible Linker DNAs [PDF]

open access: yesBiophysical Journal, 2009
In the cell nucleus, DNA wraps around histone proteins, forming nucleosome particles, and packs into a highly negatively charged structure, the chromatin. The linker histone is a protein that binds to the nucleosome and determines how the nucleosomes are linked to each other. To simulate the nucleosome-linker histone interactions, we applied a Brownian
Georgi V. Pachov, Rebecca C. Wade
openaire   +2 more sources

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