Results 61 to 70 of about 4,098,264 (291)
A new series of nitrogen and sulfur heterocyclic systems were efficiently synthesized by linking the following four rings: indole; 1,2,4-triazole; pyridazine; and quinoxaline hybrids. The strength of the acid that catalyzes the condensation of 4-amino-5-(
Ahmed T. A. Boraei+3 more
doaj +1 more source
PROTACs: The Future of Leukemia Therapeutics
The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies ...
Zubair Anwar+6 more
doaj +1 more source
Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components
Immunotoxins and antibody-drug conjugates are protein-based drugs combining a target-specific binding domain with a cytotoxic domain. Such compounds are potentially therapeutic against diseases including cancer, and several clinical trials have shown ...
Luigi Cattel, Paola Brusa, Franco Dosio
doaj +1 more source
Direct Patterning of a Cyclotriveratrylene Derivative for Directed Self-assembly of C60 [PDF]
A novel apex-modified cyclotriveratrylene (CTV) derivative with an attached thiolane-containing lipoic acid linker was directly patterned onto gold substrates via dip-pen nanolithography (DPN).
Becker, Daniel P.+3 more
core +3 more sources
The linker peptide of the ArsA ATPase [PDF]
Plasmid R773 encodes an As(III)/Sb(III)‐translocating ATPase that confers resistance to those metalloids in Escherichia coli. The catalytic subunit of the pump, the ArsA ATPase, consists of homologous N‐ and C‐terminal nucleotide‐binding domains connected by a 25‐residue linker.
Jiaxin Li, Barry P. Rosen
openaire +3 more sources
OmDet: Large‐scale vision‐language multi‐dataset pre‐training with multimodal detection network
The advancement of object detection (OD) in open‐vocabulary and open‐world scenarios is a critical challenge in computer vision. OmDet, a novel language‐aware object detection architecture and an innovative training mechanism that harnesses continual ...
Tiancheng Zhao, Peng Liu, Kyusong Lee
doaj +1 more source
Differential geometry is a powerful tool in various branches of science, especially in theoretical physics. Ordinary differential geometry requires differentiable manifolds.
Linker, Patrick
core +1 more source
N,N,N-Triethyl-4-(1H-pyrrol-1-yl)butan-1-aminium Perchlorate
Polypyrroles attract significant attention as the promising class of conductive polymers for the organic electronics, electrochemical energy-storage, photovoltaics, sensing and light-emitting devices due to their electrochemical and electrical properties.
Vasiliy V. Potapenkov+2 more
doaj +1 more source
Acylsulfonamide safety-catch linker : promise and limitations for solid-phase oligosaccharide synthesis [PDF]
Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated ...
Collot, M.+3 more
core +2 more sources
Anti-Fungal Hevein-like Peptides Biosynthesized from Quinoa Cleavable Hololectins
Chitin-binding hevein-like peptides (CB-HLPs) belong to a family of cysteine-rich peptides that play important roles in plant stress and defense mechanisms. CB-HLPs are ribosomally synthesized peptides that are known to be bioprocessed from the following
Shining Loo+6 more
doaj +1 more source