Results 61 to 70 of about 4,236,805 (394)

A new method for constructing linker scanning mutants [PDF]

, 1987
A new procedure for the construction of linker scanning mutants is described. A plasmid containing the target DNA is randomly linearized and slightly shortened by a novel combination of established methods.
Luckow, Bruno, Renkawitz, Rainer, Schütz, Günther   +2 more
core   +2 more sources

Linker Histone in Diseases [PDF]

International Journal of Biological Sciences, 2017
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in the nucleus. Accumulating evidences suggest that the linker histone is essential in the pathogenesis of several diseases.
Ye, Xin, Feng, ChuanLin, Gao, Tian, Mu, Guanqun, Zhu, Weiguo, Yang, Yang   +5 more
openaire   +2 more sources

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Internally and externally headed relative clauses in Tagalog

Glossa, 2017
Head nominals in Tagalog relative clauses can surface in three distinct positions: preceding the clause, immediately following the embedded verb, and in argument position within the clause. This paper accounts for these possibilities by positing that the
Edith Aldridge
doaj   +2 more sources

GeoVectors: A Linked Open Corpus of OpenStreetMap Embeddings on World Scale [PDF]

, 2021
Nicolas Tempelmeier, Simon Gottschalk, Elena Demidova   +2 more
openalex   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Antibody drug conjugates

Indian Journal of Medical and Paediatric Oncology, 2020
Antibody drug conjugates (ADCs) are chemically engineered drugs consisting of monoclonal antibody (mAb) and cytotoxic compound attached chemically by a linker. Upon attachment to a specific target antigen, ADC enters into the cell and payload is released,
Stalin Bala, Siva K Prasad
doaj   +1 more source

Tuning the Cross-Linker Crystallinity of a Stretchable Polymer Semiconductor

Chemistry of Materials, 2018
The cross-linking of conjugated polymers has been demonstrated to be an effective strategy to improve its elastic properties to give deformable semiconductors for plastic electronics. While there have been extensive studies of the structural requirements
G. Wang, Yu-Qing Zheng, Song Zhang, Jiheong Kang, Hung‐Chin Wu, A. Gasperini, Hongyi Zhang, X. Gu, Zhenan Bao   +8 more
semanticscholar   +1 more source

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

Antibody-drug conjugates in cancer therapy: applications and future advances

Frontiers in Immunology
Antibody-Drug Conjugates (ADCs) represent an emerging cancer therapeutic strategy and are becoming increasingly significant in the field of public health.
Rou Long, Hanrong Zuo, Guiyang Tang, Chaohui Zhang, Xinru Yue, Jinsai Yang, Xinyu Luo, Yuqi Deng, Jieya Qiu, Jiale Li, Jianhong Zuo, Jianhong Zuo, Jianhong Zuo, Jianhong Zuo   +13 more
doaj   +1 more source