Results 91 to 100 of about 2,865,343 (269)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
IK: tijdschrift over intellectueel kapitaal, 2011 IK: tijdschrift over intellectueel kapitaal 10 (2) p.
openaire +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Existence of a bound state solution for quasilinear Schrödinger equations
Advances in Nonlinear Analysis, 2017 In this article, we establish the existence of bound state solutions for a class of quasilinear Schrödinger equations whose nonlinear term is asymptotically linear in ℝN{\mathbb{R}^{N}}.
Xue Yan-Fang, Tang Chun-Lei
doaj +1 more source
Linking Climate Change Adaptation and Mitigation: A Review with Evidence from the Land-Use Sectors
Land, 2018 There is extensive scientific evidence that both adaptation and mitigation are essential to address the problem of climate change. However, there is still limited knowledge about the possibilities for exploiting the interrelationships between these ...
Rico Kongsager
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Asymmetric critical fractional p-Laplacian problems
Electronic Journal of Differential Equations, 2017 We consider the asymmetric critical fractional p-Laplacian problem $$\displaylines{ (-\Delta)^s_p u = \lambda |u|^{p-2} u + u^{p^\ast_s - 1}_+,\quad \text{in } \Omega;\cr u = 0, \quad \text{in } \mathbb{R}^N\setminus\Omega; }$$ where $\lambda>0 ...
Li Huang, Yang Yang
doaj
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source