Results 51 to 60 of about 985,482 (293)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

The effect of conjugated linoleic acid on the proliferation, migration and invasion of a murine mammary cancer cell line [PDF]

, 2002
Conjugated Linoleic Acid (CLA), a polyunsaturated fatty acid, refers to a group of dienoic derivatives of linoleic acid that can be found in natural food sources, such as milk fat and the meat of ruminant animals.
O'Connor, Áine
core   +2 more sources

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Conjugated Linoleic Acid: A Functional Food? [PDF]

International Journal of Immunopathology and Pharmacology, 2003
Scientific interest in conjugated linoleic acid (CLA) started in 1987 when Michael Pariza's team of Wisconsin University observed its inhibitory effects on chemically induced skin tumors in mice. Numerous studies have since examined CLA's role in cancer, immune function, oxidative stress, atherosclerosis, lipid and fatty acids metabolism, bone ...
N, D'Orazio, C, Ficoneri, G, Riccioni, P, Conti, T C, Theoharides, M R, Bollea   +5 more
openaire   +2 more sources

Dietary supplementation with conjugated linoleic acid plus n-3 polyunsatturated fatty acid increases food intake and brown adipose tissue in rats [PDF]

, 2009
Peer ...
Sharon Mitchell, Morris, Amanda C, D. Vernon Rayner, Klaus Wahle, Lynda Williams, Mitchell, Sharon E, Klaus W. Wahle, Wahle, Klaus W, Alan Sneddon, Williams, Lynda M, Jung-Heun Ha, Amanda C. Morris, Ha, Jung-Heun, Sneddon, Alan A, Alan A. Sneddon, Bashir, Shabina, Shabina Bashir, Amanda Morris, Sharon E. Mitchell, Lynda M. Williams, Rayner, D Vernon   +20 more
core   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Conjugated linoleic acid (CLA) and obesity [PDF]

Public Health Nutrition, 2007
AbstractBackgroundThe term conjugated linoleic acid (CLA) refers to several positional and geometric conjugated dienoic isomers of linoleic acid (LA), of which the trans-10,cis-12 isomer has been reported to reduce adiposity and increase lean mass in mice and other animals when included at ≤1% of the diet.
Manuela-Belén, Silveira, Raffaele, Carraro, Susana, Monereo, Javier, Tébar   +3 more
openaire   +2 more sources

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Effets des acides gras conjugués sur les composantes de la dépense énergétique chez la souris et le hamster

Oléagineux, Corps gras, Lipides, 2005
We measured the effects of feeding conjugated linoleic acids (CLA) on the various components of energy expenditure in two species known to react differently to CLA treatments, the hamster and the mouse.
Even Patrick, Bouthegourd Jean-Christophe, Martin Jean-Charles, Quignard Boulangé Annie   +3 more
doaj   +1 more source

Conjugated Linoleic Acid Isomers and Cancer , [PDF]

The Journal of Nutrition, 2007
We reviewed the literature regarding the effects of conjugated linoleic acid (CLA) preparations enriched in specific isomers, cis9, trans11-CLA (c9, t11-CLA) or trans10, cis12-CLA (t10, c12-CLA), on tumorigenesis in vivo and growth of tumor cell lines in vitro.
Nirvair S, Kelley, Neil E, Hubbard, Kent L, Erickson   +2 more
openaire   +2 more sources