Liothyronine for hypothyroidism: a candidate for disinvestment or in need of further research? A value of information analysis [PDF]
BMJ Open, 2021 Objective Medicines with limited evidence of effectiveness are prime candidates for disinvestment. However, investment in further research may be preferable to deimplementation, given that the absence of evidence is not evidence of absence, and research ...
Dyfrig A Hughes +3 more
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Nice guideline on thyroid disease: where does it take us with liothyronine? [PDF]
Thyroid Research, 2020 The new NICE guidelines on thyroid disease and its management do not recommend the routine use of liothyronine, but do not completely rule it out either.
Graham P. Leese
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Changes in Thyroid Metabolites after Liothyronine Administration: A Secondary Analysis of Two Clinical Trials That Incorporated Pharmacokinetic Data [PDF]
Metabolites, 2022 We examined relationships between thyroid hormone (TH) metabolites in humans by measuring 3,5-diiodothyronine (3,5-T2) and 3-iodothyronamine (3-T1AM) levels after liothyronine administration.
Nour Diab +5 more
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Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study [PDF]
Frontiers in Endocrinology, 2021 BackgroundThyroid hormones are essential for the full thermogenic response of brown adipose tissue (BAT) and have been implicated in dermal temperature regulation.
Betty Ann Bjerkreim +17 more
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Combination Thyroid Hormone Replacement; Knowns and Unknowns [PDF]
Frontiers in Endocrinology, 2019 Hypothyroidism is common throughout the world and readily diagnosed with thyroid function tests. Management should be straightforward but appears not to be the case.
Peter N. Taylor +5 more
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Case Report: A homozygous selenocysteine insertion sequence-binding protein 2 (SECISBP2) gene mutation in a pediatric patient [PDF]
Frontiers in PediatricsSelenocysteine insertion sequence-binding protein 2 (SECISBP2) is crucial for the biosynthesis of selenoproteins, including iodothyronine deiodinases, which play a vital role in thyroid hormone metabolism.
Lina Almohammadi +5 more
doaj +2 more sources
Role of T3 in Management of Hypothyroidism [PDF]
Indian Journal of Endocrinology and MetabolismThe management of hypothyroidism is based on the assumption that levothyroxine monotherapy normalizes thyroid hormone homeostasis, rendering patients clinically and biochemically euthyroid.
Sanjay Kalra +4 more
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Canadian Endocrinologists' Perspectives on Treatment With Thyroid Hormone Substitutions in Euthyroid and Hypothyroid Patients: A 2023 THESIS Questionnaire Survey. [PDF]
Clin Endocrinol (Oxf)Objective: The practice of treating hypothyroid and euthyroid patients with thyroid hormones varies between countries, as observed in the recent surveys of European thyroid experts, THESIS.
Liu A +11 more
europepmc +3 more sources
Combination therapy of liothyronine and levothyroxine for hypothyroidism-induced dilated cardiomyopathy [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2023 Youngha Choi +7 more
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