Results 121 to 130 of about 2,921 (250)

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, Volume 13, Issue 25, 4 May 2026.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Thyroid hormone use in clinical practice by Israeli endocrinologists: a THESIS* questionnaire survey

Thyroid Research
Objective Several thyroid hormone formulations are available for treatment of hypothyroidism. This study aimed at evaluating the use of these treatment options by Israeli endocrinologists in various clinical scenarios.
Liat Sasson, Keren Kaminer, Chagit Adler Cohen, Laszlo Hegedüs, Roberto Negro, Endre V. Nagy, Enrico Papini, Petros Perros, Roberto Attanasio, Eyal Robenshtok   +9 more
doaj   +1 more source

Development of a Machine Learning‐Based Predictive Model for Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Central lymph nodes metastasis (CLNM) is common in papillary thyroid. Microcarcinoma (PTMC). Whilst prophylactic central lymph node dissection (CLND) can prevent further CLNM, it remains controversial. An accurate model to predict CLNM is therefore necessary for patients with PTMC.
Tao Li, Thomas O. Butler, Yaopeng Hu, Sha Li   +3 more
wiley   +1 more source

A Comparison of Therapeutic Regimens in the Treatment of Hypothyroidism

, 2022
Hypothyroidism is a chronic medical condition that results in the inadequate production of thyroid hormones. Thyroid hormones are essential for the metabolism of almost every organ in the body.
Cranley, Christina M.
core  

What Is Your Diagnosis? Superficial Cervical Lymph Node Cytology

Veterinary Clinical Pathology, EarlyView.
Vinicius N. Hirata, Rúbia S. da Silva, Francisca B. Lang, Augusto de Oliveira, Cinthia M. de Andrade   +4 more
wiley   +1 more source

Co‐Occurrence of Agminated Lentigines, Café‐Au‐Lait Macules, and Vitiligo: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Lentigines, café‐au‐lait macules (CALMs), and vitiligo are pigmentary disorders that seldom occur together in a single individual. Their co‐occurrence may indicate underlying genetic syndromes requiring differential diagnosis. We report an 18‐year‐old male who developed CALMs at age 11, agminated lentigines at age 13, and vitiligo on the right
Xinxin Lei, Bo Xie
wiley   +1 more source

Oncogenic driver and therapeutic target: Prolactin signalling axis in retroperitoneal sarcoma

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Retroperitoneal sarcoma cells can secrete prolactin into the bloodstream, inducing hyperprolactinaemia, which subsequently triggers metabolic reprogramming, such as glucose metabolism. SOX4 can function as a transcription factor that facilitates PRL transcription.
Fu'an Xie, Lingwei Gu, Kunrong Yang, Shuai Wang, Mengmeng Xiao, Guangting Yan, Quan Zhang, Rubing Liang, Aobo Zhuang, Zhe Xi, Yujia Niu, Yanhua Chen, Xiaogang Xia, Linlin Qu, Bin Zhao, Weibing Li, Ting Wu, Chundong Yu, Chenghua Luo, Houzhao Wang, Lanlan Lian, Wengang Li   +21 more
wiley   +1 more source

An Evaluation of Longitudinal Thyroid Hormone Levels Over the Years Before and After Patients Started on Levothyroxine

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
Free thyroxine (FT4) median (interquartile range) and percentage FT4 within reference range for patients pre‐ and post‐levothyroxine (LT4) treatment versus untreated individuals. ABSTRACT Introduction This retrospective study aimed to investigate how free thyroxine (FT4) and thyroid‐stimulating hormone (TSH) levels change in the years pre‐ and post ...
Michael Stedman, Peter Taylor, Ian Halsall, David Halsall, Buchi Okosieme, Suhani Bahl, Sangeeth Veluchamy, Lakdasa Premawardhana, Anthony A. Fryer, Colin Dayan, Adrian Heald   +10 more
wiley   +1 more source

Comparative Efficacy and Safety of Resmetirom and Efruxifermin for Metabolic Dysfunction‐Associated Steatohepatitis: A Network Meta‐Analysis of Randomized Controlled Trials

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This meta‐analysis compared Resmetirom and Efruxifermin in patients with MASH, focusing on improvements in key biochemical and non‐invasive markers. Efruxifermin is associated with favourable outcomes with a slightly greater effect on MRI‐PDFF and AST, along with more comparable safety outcomes.
Doha Jaber, Inas Jaber, Ayah Abu Lehia, Thekrayat Asad, Hazem Ayesh   +4 more
wiley   +1 more source

Combination therapy of liothyronine and levothyroxine for hypothyroidism-induced dilated cardiomyopathy [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2023
Youngha Choi, Se Yong Jung, Jung Min Park, Junghwan Suh, Eun Jung Shin, Hyun Wook Chae, Ho-Seong Kim, Ahreum Kwon   +7 more
doaj   +1 more source