Results 111 to 120 of about 202,412 (300)

Caracterização bioquímica de duas lipases mutantes de Staphylococcus xylosus e de uma esterase de Lactobacillus plantarum imobilizada em polipropileno [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Ciência dos Alimentos, Florianópolis, 2010As lipases e esterases pertencem ao grupo das hidrolases e são enzimas capazes de ...
Kolling, Deise Juliana
core  

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Pore size of macroporous polystyrene microspheres affects lipase immobilization

, 2010
Polystyrene (PST) microspheres are commonly chosen as immobilization carriers due to their unique advantages such as ideal mechanical strength, adjustable particle size, and favorable chemical stability.
Zhou, WQ, Gao, Fei, Li, Yan, Wei, Wei, Zhou, Wei-Qing, Qu, Jian-Bo, Ma, Guang-Hui, Wei-Qing Zhou, Guang-Hui Ma, Wei Wei, Fei Gao, Jian-Bo Qu, Yan Li   +12 more
core   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Lipase-Catalyzed Ring-Opening Polymerization of Trimethylene Carbonate^†

, 2016
This work was directed at extending the use of lipase-catalyzed ring-opening polymerizations to cyclic carbonate monomers. Of the seven lipases screened for bulk trimethylene carbonate (TMC) polymerization (70 °C, 120 h), Novozym-435 from Candida ...
Yuri Y. Svirkin (3058944), Lori A. Henderson (3058941), Kirpal S. Bisht (622080), Richard A. Gross (1450531), Graham Swift (3002331), David L. Kaplan (131325)   +5 more
core   +1 more source

Artificial Cell Catalysts for Biotransformation: Design Principles and Process Integration

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Artificial cell catalysts are emerging as programmable biocatalytic platforms for sustainable molecular conversion. By reconstituting enzymes and functional modules within synthetic compartments, they combine the selectivity of biological catalysis with the design flexibility of synthetic materials.
Iori Kobayashi, Shogo Yoshimoto, Katsutoshi Hori   +2 more
wiley   +1 more source

Impact of scaled-down on dissolved oxygen fluctuations at different levels of the lipase synthesis pathway of Yarrowia lipolytica [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2010
The impact of the fluctuations in dissolved oxygen tension (DOT) on the lipase production by Yarrowia lipolytica has been investigated in a scale-down reactor (SDR). This bioreactor comprises a 20 l agitated vessel with an automatic valve controlling the
Delvigne, F., Thonart, P., Destain, J., Kar, T.   +3 more
doaj  

Lipase-Catalyzed Production of (S)‑Carprofen Enhanced by Hydroxyethyl-β-cyclodextrins: Experiment and Optimization

, 2019
Stereoselective resolution of (R,S)-carprofen methyl ester (CPOMe) by lipase-catalyzed hydrolysis to (S)-carprofen (CP) was investigated in an aqueous medium.
Kewen Tang (2020891), Guangyong Liu (6584216), Kewen Tang, Xin Yuan (174619), Weifeng Xu (66792), Panliang Zhang, Weifeng Xu, Xin Yuan, Guangyong Liu, Panliang Zhang (2020894)   +9 more
core   +1 more source

Species Dynamics and Gene Expression in Algal Polycultures Under Mixotrophic Cultivation in Outdoor Pilot‐Scale Nordic Conditions

Biotechnology and Bioengineering, EarlyView.
These results demonstrate that mixotrophic conditions drive both microbial community shifts and metabolic reprogramming, underscoring the importance of cultivation strategy and polyculture selection for targeted applications such as nutrient recovery and bioproduct generation.
Quyen Nham, Hanna Farnelid, Catherine Legrand, Elin Lindehoff   +3 more
wiley   +1 more source

Lipase-Catalyzed Enantioselective Copolymerization of Substituted Lactones to Optically Active Polyesters

, 2016
Enantioselective copolymerization of racemic substituted lactones with achiral lactones has been examined by using Candida antarctica lipase as catalyst.
Shiro Kobayashi (355356), Hiroshi Uyama (624309), Hirofumi Kikuchi (3057354)   +2 more
core   +1 more source