Results 131 to 140 of about 196,719 (298)

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Endothelial lipase: a new lipase on the block.

Journal of lipid research, 2003
Endothelial lipase (EL) is a newly described member of the triglyceride lipase gene family. It has a considerable molecular homology with lipoprotein lipase (LPL) (44%) and hepatic lipase (HL) (41%). Unlike LPL and HL, this enzyme is synthesized by endothelial cells and functions at the site where it is synthesized. Furthermore, its tissue distribution
Sungshin Y, Choi, Ken-ichi, Hirata, Tatsuro, Ishida, Thomas, Quertermous, Allen D, Cooper   +4 more
openaire   +1 more source

Xylose Acetals ‐ a New Class of Sustainable Solvents and Their Application in Enzymatic Polycondensation

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Novel organic solvents with an unmodified carbohydrate core were synthesised both from D‐xylose and directly from biomass and were successfully used as reaction media for lipase biocatalysts to synthesise aliphatic and aromatic polyesters. Abstract The use of organic solvents in academic research and industry applications is facing increasing ...
Anastasia O. Komarova, Cicely M. Warne, Hugo Pétremand, Laura König‐Mattern, Johannes Stöckelmaier, Chris Oostenbrink, Georg M. Guebitz, Jeremy Luterbacher, Alessandro Pellis   +8 more
wiley   +1 more source

Redox Biocatalysis in Lidocaine‐Based Hydrophobic Deep Eutectic Solvents: Non‐Conventional Media Outperform Aqueous Conditions

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Two hydrophobic DESs, lidocaine/oleic acid and lidocaine/decanoic acid, were utilized as reaction media that were enzyme‐compatible and highly substrate‐solubilizer for carbonyl reduction catalyzed by horse liver alcohol dehydrogenase, focusing on the effect of water contents and on maximizing substrate loadings, which showcases for the first time the ...
Ningning Zhang, Viktoria Lahmann, Jan Philipp Bittner, Pablo Domínguez de María, Sven Jakobtorweihen, Irina Smirnova, Selin Kara   +6 more
wiley   +1 more source

Lipase-catalysed synthesis of palm oil-omega-3 structured lipids

, 2019
Candida antarctica lipase A was applied to selectively remove saturated fatty acids from palm oil. Rhizomucor miehei lipase was then used to add EPA or ALA into the partially hydrolyzed palm oil to produce new palm oil structured lipids containing ...
Wenrong Yang (13099785), B Wang (805040), TO Akanbi (14450037), Colin Barrow (13063191), R Li (660811), Q Xia (9977135)   +5 more
core  

Lipase-Entrapped Polydopamine (PDA) Nanobottles for Near-Infrared (NIR)-Triggered Pickering Interfacial Biocatalysis (PIB)

In this work, we presented an external stimulating Pickering interfacial biocatalyst (PIB), which is a gelatin and Candida rugosa lipase (CRL) complex containing polydopamine (PDA) nanobottles (PDA@G-CRL).
Jin Mao (5346110), Qianchun Deng (1412569), Zhonglin He (6239231), Qi Zhou (7408), Jie Shi (130059), Xingxing Ding (11395832), Lei Zheng (106363)   +6 more
core   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Green synthesis and effective utilization of biogenic Al2O3-nanocoupled fungal lipase in the resolution of active homochiral 2-octanol and its immobilization via aluminium oxide nanoparticles

Green Processing and Synthesis
The present study highlights the true potential of Rhizopus oligosporus IIB-08 to produce lipase enzyme under solid-state fermentation and focuses on improving the properties of lipase by immobilizing it on biogenic aluminium oxide nanoparticles (Al-NPs)
Ali Sikander, Tahir Ghanwa, Usman Ahmad Muhammad, Liaqat Iram, Nauman Aftab Muhammad, Khurshid Shazia, Khan Jahangir, Sarwar Abid, Aziz Tariq, Alharbi Metab, Alasmari Abdullah F., Albekairi Thamer H.   +11 more
doaj   +1 more source

Produção de diacilgliceróis a partir da glicerólise enzimática de óleo de peixe utilizando meio com surfactante de grau alimentício [PDF]

, 2011
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Alimentos, Florianópolis, 2011Nas pesquisas com óleos e gorduras alimentícios, estudos vêm indicando que os produtos ricos em ...
Santos, Joanna Silva
core  

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source