Results 31 to 40 of about 196,719 (298)

Lipase inhibition attenuates the acute inhibitory effects of oral fat on food intake in healthy subjects [PDF]

, 2003
The lipase inhibitor, orlistat, is used in the treatment of obesity and reduces fat absorption by about 30%. However, the mean weight loss induced by orlistat is less than expected for the degree of fat malabsorption.
O'Donovan, D., Wishart, J., Horowitz, M., Feinle-Bisset, C.   +3 more
core   +1 more source

Effect of Multiple Gene Copy Number of Bacterial Lipase to Increase Lipase Production in Pichia pastoris

Hayati Journal of Biosciences
Bacterial lipase poses potential challenges when expressed in eukaryotic protein expression systems such as Pichia pastoris. This research aims to increase extracellular T1.2RQ lipase secretion (free lipase) with multiple gene copy number strategies in ...
Esti Puspitasari, Yepy Hardi Rustam, Andreas Adhi Satya, Antonius Suwanto, Aris Tri Wahyudi, Rika Indri Astuti   +5 more
doaj   +1 more source

Structural investigations of the regio- and enantioselectivity of lipases [PDF]

, 1998
Although lipases are widely applied for the stereospecific resolution of racemic mixtures of esters, the atomic details of the factors that are responsible for their stereospecificity are largely obscure. We determined the X-ray structures of Pseudomonas
Dietmar A Lang, Dietmar A. Lang, Bauke W Dijkstra, Lang, Dietmar A., Dijkstra, Bauke W., Dijkstra, Bauke W.,, Bauke W. Dijkstra, Lang, Dietmar A.,   +7 more
core   +2 more sources

Study the effect of F17S mutation on the chimeric Bacillus thermocatenulatus lipase

Journal of Genetic Engineering and Biotechnology, 2016
Lipases (triacylglycerol acylhydrolase, EC 3.1.1.3) are one of the highest value commercial enzymes as they have potential applications in biotechnology for detergents, food, pharmaceuticals, leather, textiles, cosmetics, and paper industries; and are ...
Seyed Hossein Khaleghinejad, Gholamreza Motalleb, Ali Asghar Karkhane, Saeed Aminzadeh, Bagher Yakhchali   +4 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Characterisation of a “green” lipase from Aspergillus niger immobilised on polyethersulfone membranes

Acta Scientiarum: Technology, 2019
In this work, a “green” Aspergillus niger lipase obtained from the solid-state fermentation of Hancornia speciosa (“mangaba”) seeds was efficiently immobilised on polyethersulfone membranes (PES) by physical adsorption (PES-ADS-lipase) and ...
Fernanda Martins de Souza, Cleide Mara Faria Soares, Alvaro Silva Lima, Luciana Cristina Lins de Aquino Santana   +3 more
doaj   +1 more source

Preparation, Characterization, and Surface Modification of Cellulose Nanocrystal from Lignocellulosic Biomass for Immobilized Lipase

Fibers, 2022
This study reports the synthesis of cellulose nanocrystal (CNC) from sugarcane bagasse and rice straw as the matrix for immobilized lipase enzyme. The CNC surface was modified using cetyltrimethylammonium bromide (CTAB) to improve the interaction of CNC ...
Elvi Restiawaty, Neng Tresna Umi Culsum, Norikazu Nishiyama, Yogi Wibisono Budhi   +3 more
doaj   +1 more source

Homology of lipoprotein lipase to pancreatic lipase. [PDF]

Proceedings of the National Academy of Sciences, 1986
Bovine milk lipoprotein lipase was subjected to amino acid sequence analysis. The first 19 amino-terminal residues were Asp-Arg-Ile-Thr-Gly-Gly-Lys-Asp-Phe-Arg-Asp-Ile-Glu-Ser-Lys-Phe-Ala-Leu- Arg. In addition, reversed-phase high-performance liquid chromatography of a tryptic digest of reduced and alkylated lipase resolved a number of peptides, five ...
C M, Ben-Avram, O, Ben-Zeev, T D, Lee, K, Haaga, J E, Shively, J, Goers, M E, Pedersen, J R, Reeve, M C, Schotz   +8 more
openaire   +2 more sources

Hydrophobic adsorption and covalent immobilization of Candida antarctica lipase B on mixed-function-grafted silica gel supports for continuous-flow biotransformations [PDF]

, 2013
Adsorption onto solid supports has proven to be an easy and effective way to improve the mechanical and catalytic properties of lipases. Covalent binding of lipases onto the support surface enhances the active lifetime of the immobilized biocatalysts ...
Poppe, László, Márkus, Mária, Abaháziová, Emese, Weiser, Diána, Kovács, Péter, Koczkac, Béla, Boros, Zoltán, Tomin, Anna, Magyar, Ágnes   +8 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source