Results 61 to 70 of about 202,412 (300)
Advanced Science, EarlyView.LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao +12 more
wiley +1 more source
Overexpression of Recombinant Lipase from in
European Journal of Inflammation, 2012 This study attempts to clone and express the extracellular lipase from Burkholderia cepacia in Escherichia coli using pET system as well as to determine the enzyme activity of recombinant lipase. The extracted DNA from B.
M. Raftari +5 more
doaj +1 more source
Lipase-Catalyzed Reactions in Ionic Liquids
, 2016 Candidaantarctica lipase was shown to catalyze alcoholysis, ammoniolysis, and perhydrolysis reactions using the ionic liquids 1-butyl-3-methylimidazolium tetrafluoroborate or hexafluorophosphate as reaction media. Reaction rates were generally comparable
K. R. Seddon (3063282) +3 more
core +1 more source
Molecular cloning and characterization of a thermostable esterase/lipase produced by a novel Anoxybacillus flavithermus strain [PDF]
, 2013 A thermophilic strain producing an extracellular esterase/lipase was isolated from a hot spring in Tǎşnad, Romania, and was identified phenotypically and by 16S rDNA sequencing as Anoxybacillus flavithermus (GenBank ID: JQ267733).
Beata G. Vértessy +13 more
core +1 more source
Advanced Science, EarlyView.A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan +14 more
wiley +1 more source
Advanced Science, EarlyView.CaMKIIδ–AUP1 signaling maintains PERK‐dependent ER homeostasis during ADM‐mediated pancreatic repair. ABSTRACT Pancreatic repair after acute pancreatitis (AP) is essential for restoring tissue integrity, but the intrinsic mechanisms coordinating acinar plasticity and regeneration remain poorly understood.
Yonghao Chen +10 more
wiley +1 more source
Advanced Science, EarlyView.A pH‐responsive ZIF‐8/2‐DG@Cu‐TA nanoplatform orchestrates multifaceted metabolic disruption for synergistic starvation‐immunotherapy. Acid‐triggered 2‐DG release blocks glycolysis, while Zn2+ overload induces mitochondrial dysfunction. Concurrently, Cx43‐mediated gap junctions redirect lipid droplets from tumor cells to cancer‐associated fibroblasts ...
Xianlong Zong +9 more
wiley +1 more source
Lipase-immobilized biocatalytic membranes for biodiesel production
, 2014 Microbial lipase from Candida rugosa (Amano AY-30) has good transesterification activity and can be used for biodiesel production. In this study, polyvinylidene fluoride (PVDF) membrane was grafted with 1,4-diaminobutane and activated by glutaraldehyde ...
Yung-Chuan Liu +4 more
core +1 more source
Lipase inhibition attenuates the acute inhibitory effects of oral fat on food intake in healthy subjects [PDF]
, 2003 The lipase inhibitor, orlistat, is used in the treatment of obesity and reduces fat absorption by about 30%. However, the mean weight loss induced by orlistat is less than expected for the degree of fat malabsorption.
O'Donovan, D. +3 more
core +1 more source
MetaPaCS: A Novel Meta‐Learning Framework for Pancreatic Cancer Subtype Identification
Advanced Intelligent Systems, EarlyView.We have developed MetaPaCS, an ensemble meta‐learning framework for reliable prediction of pancreatic cancer subtypes with high accuracy. MetaPaCS is capable of capturing subtype‐specific distinct gene expression patterns and drug‐disease associations for pancreatic cancer.
Nick B. Peterson +4 more
wiley +1 more source