Results 171 to 180 of about 890,691 (262)

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

EVALI Presenting as Diffuse Alveolar Hemorrhage in an Adolescent. Case Report. [PDF]

Pediatr Pulmonol
Hompanera SD, Cuesta PL, Martínez LP.
europepmc   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Myeloid deficiency of RORα exacerbates lipid dysregulation and laser-induced choroidal neovascularization. [PDF]

Angiogenesis
Kushwah N, Liu CH, Bora K, Maurya M, Pavlovich MC, Fu Z, Kamenecka TM, Sun Y, Solt LA, Chen J.   +9 more
europepmc   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Exogenous lipoid pneumonia from chronic mineral oil aspiration complicated by cavitary <i>Mycobacterium abscessus</i> infection. [PDF]

Radiol Case Rep
Salem MB, Abubaker K, Alzoubi Y, Alzghoul H, Faruqi I.   +4 more
europepmc   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Integrative bioinformatics analysis identifies APOE as a candidate link between lipid dysregulation and macrophage activation in inborn errors of metabolism. [PDF]

Front Pharmacol
Satria RD, Kusuma RH, Isnani N, Sukorini U, Ratnaningsih T, Herningtyas EH, Intansari US, Windarwati, Harahap NIF, Syaifullah PH, Hikmatul KR, Bodiwan LL, Prabasaktya RW, Santoso NM, Darmawan MAPA, Mugiyanto E, Ardianto B, Irham LM, Lin CF, Chen CL, Adikusuma W.   +20 more
europepmc   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Exploring the Crosstalk Between Iron Homeostasis and Antioxidant Systems in Ferroptosis Regulation within Immunosuppressive Macrophages

reservedFerroptosis is a recently identified form of cell death driven by iron-dependent lipid peroxidation (LPO). Recent studies link ferroptosis to both classical and alternative activation in macrophages depending on the model and the context.
ANGIONI, GIULIA
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